Background

Inflammatory derivatives of free fatty acids are involved in the development of neuroinflammation and cognitive dysfunctions. The study aim was to establish the influence of eicosanoids on the cognitive status of stroke patients.

Methods

73 stroke patients were prospectively evaluated towards the neuropsychological cognitive functions on the 7th day after stroke and after follow-up of 6 months. Eicosanoids levels were measured in all patients and compared to stroke-free controls (n = 30).

Results

Prostaglandin E2 was negatively correlated with Montreal Cognitive Assessment (MOCA) test on the 7th day after stroke. The level of 9-hydroxyoctadecadienoic acid (9S-HODE) was significantly higher in patients with cognitive dysfunctions in MOCA test compared to the others (group I mean ± SD: 0.040 ± 0.035 vs. group II: 0.0271 ± 0.016). In the initial neuropsychological assessment maresin 1-, 5-hydroxyeicosatetraenoic acid (HETE), 12S-HETE and 15S-HETE were negatively correlated with California Verbal Learning Test (CVLT) and thus with cognitive functions, while in the follow-up examination negative correlations were identified for prostaglandin E2, meresin 1, leukotriene B4, 13S HODE, 9S-HODE; the only positive correlation was observed in 15S-HETE. Other neuropsychological tests showed a beneficial impact of resolvin D1 and a negative role of prostaglandin E2 was observed in the first examination and in the follow-up. Resolvin D1 and the group of all analyzed eicosanoids predict changes in cognitive functions.

Conclusions

Eicosanoids can play a role in the neuroinflammation. They can affect the cognitive status at the stroke onset and have a predictive value for post-stroke cognitive decline. Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are the most important inflammatory free fatty acid derivatives in the cognitive functions in stroke. Eicosanoids predict post-stroke cognitive functions.

中文翻译：

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前列腺素 E2、9S-、13S-HODE 和 resolvin D1 与中风后认知障碍密切相关

 背景

游离脂肪酸的炎症衍生物参与神经炎症和认知功能障碍的发展。该研究的目的是确定类二十烷酸对中风患者认知状态的影响。

 方法

对73名脑卒中患者在脑卒中后第7天及随访6个月后进行神经心理认知功能前瞻性评估。测量了所有患者的类二十烷酸水平，并与无中风对照者进行比较（ n = 30）。

 结果

前列腺素E2与中风后第7天的蒙特利尔认知评估（MOCA）测试呈负相关。 MOCA测试中认知功能障碍患者的9-羟基十八碳二烯酸（9S-HODE）水平显着高于其他患者（I组平均值±SD：0.040±0.035 vs II组：0.0271±0.016）。在最初的神经心理学评估中，maresin 1-, 5-羟基二十碳四烯酸 (HETE)、12S-HETE 和 15S-HETE 与加州言语学习测试 (CVLT) 呈负相关，从而与认知功能呈负相关，而在后续检查中呈负相关鉴定出前列腺素 E2、meresin 1、白三烯 B4、13S HODE、9S-HODE；唯一的正相关是在 15S-HETE 中观察到的。其他神经心理学测试显示，在第一次检查和后续检查中，观察到消退素 D1 具有有益作用，而前列腺素 E2 具有负面作用。 Resolvin D1 和所有分析的类二十烷酸组可预测认知功能的变化。

 结论

类二十烷酸可以在神经炎症中发挥作用。它们可以影响中风发作时的认知状态，并对中风后认知能力下降具有预测价值。前列腺素 E2、9S-、13S-HODE 和 resolvin D1 是中风认知功能中最重要的炎症性游离脂肪酸衍生物。类花生酸可以预测中风后的认知功能。