There is strong comorbidity between atherosclerosis (ATS) and depression which is attributed to increased atherogenicity, insulin resistance (IR), and immune and oxidative stress.

To examine the role of the above pathways and mu-opioid receptor (MOR), β-endorphin levels, zinc, copper, vitamin D3, calcium, and magnesium in depression due to ATS/unstable angina (UA).

Biomarkers were assayed in 58 controls and 120 ATS patients divided into those with moderate and severe depression according to the Beck Depression Inventory-II (BDI-II) scores >19 and >29, respectively.

Neural network and logistic regression models showed that severe depression due to ATS/UA was best predicted by interleukin-6 (IL-6), UA, MOR, zinc, β-endorphin, calcium and magnesium, and that moderate depression was associated with IL-6, zinc, MOR, β-endorphin, UA, atherogenicity, IR, and calcium. Neural networks yielded a significant discrimination of severe and moderate depression with an area under the receiver operating curves of 0.831 and 0.931, respectively. Using Partial Least Squares path analysis, we found that 66.2% of the variance in a latent vector extracted from ATS/UA clinical features, and the BDI-II scores, atherogenicity, and IR could be explained by the regression on IL-6, IL-10, zinc, copper, calcium, MOR, and age. The BDI-II scores increased from controls to ATS to UA class III to UA class IV.

Immune activation, the endogenous opioid system, antioxidants, trace elements, and macrominerals modulate a common core shared by increased depressive symptoms, ATS, UA, atherogenicity, and IR.

动脉粥样硬化 (ATS) 和抑郁症之间存在很强的共病，这归因于动脉粥样硬化、胰岛素抵抗 (IR) 以及免疫和氧化应激的增加。

检查上述途径和 μ-阿片受体 (MOR)、β-内啡肽水平、锌、铜、维生素 D3、钙和镁在 ATS/不稳定型心绞痛 (UA) 引起的抑郁症中的作用。

根据 Beck 抑郁量表-II (BDI-II) 评分分别 >19 和 >29，在 58 名对照者和 120 名 ATS 患者中检测了生物标志物，这些患者分为中度和重度抑郁症患者。

神经网络和逻辑回归模型表明，ATS/UA 引起的重度抑郁最好由白细胞介素 6 (IL-6)、UA、MOR、锌、β-内啡肽、钙和镁预测，而中度抑郁与 IL 相关-6、锌、MOR、β-内啡肽、UA、致动脉粥样化、IR 和钙。神经网络对重度和中度抑郁症产生了显着的区分，接受者操作曲线下的面积分别为 0.831 和 0.931。使用偏最小二乘路径分析，我们发现从 ATS/UA 临床特征和 BDI-II 评分、致动脉粥样化和 IR 中提取的潜在向量中有 66.2% 的方差可以通过 IL-6、IL 的回归来解释-10、锌、铜、钙、MOR 和年龄。BDI-II 分数从对照组增加到 ATS 到 UA III 级到 UA IV 级。

免疫激活、内源性阿片系统、抗氧化剂、微量元素和常量矿物质调节由抑郁症状增加、ATS、UA、致动脉粥样化和 IR 共享的共同核心。