当前位置: X-MOL 学术Science › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Supplements to treat prediabetes
Science ( IF 44.7 ) Pub Date : 2021-06-11 , DOI: 10.1126/science.abj0764
Chelsea Hepler 1 , Joseph Bass 1
Affiliation  

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolic co-factor that is central to energy metabolism. During aging, obesity, and diabetes, NAD+ concentrations in cells decline. NAD+ is synthesized de novo from tryptophan precursors, from nicotinic acid through the Preiss-Handler pathway, or from nicotinamide through the salvage pathway. The rate-limiting enzyme in the salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT), recycles nicotinamide into nicotinamide mononucleotide (NMN), which is converted into NAD+ (see the figure). Restoration of NAD+ concentrations in cells of old or diseased mice through administration of NMN improves health; however, it is unclear whether NMN therapy is practical in humans. On page 1224 of this issue, Yoshino et al. (1) show in a randomized, placebo-controlled, double-blind trial that NMN supplementation promotes NAD+ metabolism and improves skeletal muscle insulin sensitivity in postmenopausal prediabetic women who are overweight or obese. Thus, NMN may be a viable therapeutic strategy in humans to improve metabolic health during obesity.



中文翻译:

治疗前驱糖尿病的补充剂

烟酰胺腺嘌呤二核苷酸 (NAD + ) 是一种重要的代谢辅助因子,对能量代谢至关重要。在衰老、肥胖和糖尿病期间,细胞中的 NAD +浓度会下降。NAD +从色氨酸前体、烟酸通过 Preiss-Handler 途径从头合成,或从烟酰胺通过补救途径从头合成。补救途径中的限速酶烟酰胺磷酸核糖基转移酶 (NAMPT) 将烟酰胺再循环为烟酰胺单核苷酸 (NMN),后者再转化为 NAD +(见图)。NAD +的恢复通过给予 NMN,老龄或患病小鼠细胞中的浓度可以改善健康;然而,尚不清楚 NMN 疗法是否适用于人类。在本期第 1224 页,Yoshino等人。( 1 ) 在一项随机、安慰剂对照、双盲试验中表明,补充 NMN 可促进超重或肥胖的绝经后糖尿病前期女性的NAD +代谢并改善骨骼肌胰岛素敏感性。因此,NMN 可能是人类改善肥胖期间代谢健康的可行治疗策略。

更新日期:2021-06-11
down
wechat
bug