Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity.

成年小鼠心室-室下区 (V-SVZ) 中的静止神经干细胞 (NSC) 被激活，生成神经元和一些神经胶质细胞。在这里，我们发现血小板源性生长因子受体β（PDGFRβ）由产生嗅球中间神经元和神经胶质细胞的成年V-SVZ NSC表达。成人 V-SVZ NSC 中 PDGFRβ 的选择性删除导致其从静止状态中释放，从而揭示了不同神经胶质细胞类型的胶质生成域。这些结构域也会在受伤时被招募。我们鉴定了脑室内少突胶质细胞祖细胞，该祖细胞源自脑室内部与室管膜上轴突接触的神经干细胞。总之，我们的研究结果表明，除了神经发生的空间域之外，成人 V-SVZ 还包含用于胶质生成的空间域。这些神经胶质源性 NSC 结构域在稳态下往往处于静止状态，可能有助于大脑的可塑性。