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PEG Modificated Bubble-Like Carbon Spherical-W18O49 Using for In Vitro Chemotherapy-Photothermal Synergistic Reverse Cancer Cells
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2021-06-10 , DOI: 10.1002/ppsc.202100062 Pengfei Yang 1 , Zhihuan Zhao 1 , Shasha Yang 1 , Jianying Lin 1 , Jimin Fan 2 , Bing Zhang 1
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2021-06-10 , DOI: 10.1002/ppsc.202100062 Pengfei Yang 1 , Zhihuan Zhao 1 , Shasha Yang 1 , Jianying Lin 1 , Jimin Fan 2 , Bing Zhang 1
Affiliation
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In this study, a chemotherapy-photothermal synergistic anti-tumor system is constructed. Both W18O49@R-C and PEG-W18O49@R-C synthesized by hydrothermal method show the potential of photothermal therapy (PTT). The structure of reflux-carbon is bubble-like spherical and W18O49@R-C obtained by hydrothermal synthesis will cause bubble collapse due to the formation of crystal W18O49; thus, the particle size decreases sharply. Furthermore, the photothermal stability of PEG-W18O49@R-C is higher than that of W18O49@R-C, and ζ-potential measurement indicates that PEG-W18O49@R-C has excellent dispersion characteristics. The test of drug loading and drug release performance show that PEG-modified W18O49@R-C has superior performance on drug loading amount and release capacity. In the synergistic anti-tumor process, the cancer cell viability after co-incubating with PEG-W18O49@R-C+DOX.HCl (with 808nm) is only 16.6%. These results indicate that PEG-W18O49@R-C has potential in the treatment of cancer by a combination of PTT and chemotherapy.
中文翻译：
PEG修饰的气泡状碳球-W18O49用于体外化疗-光热协同逆转癌细胞
本研究构建了化疗-光热协同抗肿瘤系统。通过水热法合成的W 18 O 49 @RC 和PEG-W 18 O 49 @RC 均显示出光热疗法（PTT）的潜力。回流碳的结构为气泡状球形，水热合成得到的W 18 O 49 @RC会因形成W 18 O 49晶体而导致气泡破裂；因此，粒径急剧减小。此外，PEG-W 18 O 49 @RC的光热稳定性高于 W 18 O 49@RC 和 ζ 电位测量表明 PEG-W 18 O 49 @RC 具有优异的色散特性。载药量和释药性能测试表明，PEG修饰的W 18 O 49 @RC在载药量和释放能力方面具有优异的性能。在协同抗肿瘤过程中，与 PEG-W 18 O 49 @R-C+DOX共培养后的癌细胞活力。HCl（808nm）仅为16.6%。这些结果表明，PEG-W 18 O 49 @RC 在通过 PTT 和化学疗法的组合治疗癌症方面具有潜力。
更新日期：2021-07-19
中文翻译：
PEG修饰的气泡状碳球-W18O49用于体外化疗-光热协同逆转癌细胞
本研究构建了化疗-光热协同抗肿瘤系统。通过水热法合成的W 18 O 49 @RC 和PEG-W 18 O 49 @RC 均显示出光热疗法（PTT）的潜力。回流碳的结构为气泡状球形，水热合成得到的W 18 O 49 @RC会因形成W 18 O 49晶体而导致气泡破裂；因此，粒径急剧减小。此外，PEG-W 18 O 49 @RC的光热稳定性高于 W 18 O 49@RC 和 ζ 电位测量表明 PEG-W 18 O 49 @RC 具有优异的色散特性。载药量和释药性能测试表明，PEG修饰的W 18 O 49 @RC在载药量和释放能力方面具有优异的性能。在协同抗肿瘤过程中，与 PEG-W 18 O 49 @R-C+DOX共培养后的癌细胞活力。HCl（808nm）仅为16.6%。这些结果表明，PEG-W 18 O 49 @RC 在通过 PTT 和化学疗法的组合治疗癌症方面具有潜力。
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