Many factors are involved in acrosome biogenesis in order for appropriate acrosome formation to occur. Here, we demonstrate that IZUMO family member 3, IZUMO3, plays an important role in acrosome biogenesis, as proven by gene disruption experiments. A loss of IZUMO3 in round spermatids affects acrosomal granule positioning due to lack of acrosomal granule contact with the inner acrosomal membrane, leading to the formation of grossly malformed spermatozoa associated with male subfertility. Thus, we suggest that mammalian spermiogenesis needs an elaborate acrosome biogenesis through IZUMO3 involvement.

中文翻译：

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IZUMO 家族成员 3，IZUMO3，通过顶体形成参与男性生育

为了发生适当的顶体形成，许多因素都参与了顶体的生物发生。在这里，我们证明 IZUMO 家族成员 3，IZUMO3，在顶体生物发生中起着重要作用，正如基因破坏实验所证明的那样。圆形精子细胞中 IZUMO3 的缺失会影响顶体颗粒的定位，因为顶体颗粒缺乏与顶体内膜的接触，导致形成与男性生育力低下相关的严重畸形精子。因此，我们建议哺乳动物精子发生需要通过 IZUMO3 参与进行精细的顶体生物发生。