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Antimicrobial Susceptibility Testing of Antimicrobial Peptides Requires New and Standardized Testing Structures
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2021-06-10 , DOI: 10.1021/acsinfecdis.1c00210
Marita Meurer 1, 2 , Deborah A O'Neil 3 , Emma Lovie 3 , Laura Simpson 3 , Marcelo D T Torres 4, 5, 6 , Cesar de la Fuente-Nunez 4, 5, 6 , Alfredo M Angeles-Boza 7, 8 , Christin Kleinsorgen 9 , Derry K Mercer 3 , Maren von Köckritz-Blickwede 1, 2
Affiliation  

The need for optimized as well as standardized test systems of novel antimicrobial peptides (AMPs) was discussed by experts in the field at the International Meeting on Antimicrobial Peptides (IMAP) 2017 and the 2019 Gordon Research Conference (GRC) on Antimicrobial Peptides, and a survey related to this topic was circulated to participants to collate opinions. The survey included questions ranging from the relevance of susceptibility testing for understanding the mode of action of AMPs, to the importance of optimization and a degree of standardization of test methods and their clinical relevance. Based on the survey results, suggestions for future improvements in the research field are made.

中文翻译:

抗菌肽的抗菌药物敏感性测试需要新的标准化测试结构

在 2017 年国际抗菌肽会议 (IMAP) 和 2019 年 Gordon 抗菌肽研究会议 (GRC) 上,该领域的专家讨论了对新型抗菌肽 (AMP) 测试系统的优化和标准化的需求,以及与该主题相关的调查已分发给参与者以整理意见。该调查包括的问题包括敏感性测试与了解 AMP 作用模式的相关性、优化的重要性和测试方法的标准化程度及其临床相关性。根据调查结果,对未来研究领域的改进提出建议。
更新日期:2021-08-13
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