Glioblastoma multiforme (GBM) or grade IV astrocytoma is the most diagnosed form of primary brain tumours in adults. Radioimmunotherapy (RIT), mostly in combination with conventional therapies, is presented in the current review as a therapeutic strategy of high potential in the management of GBM. A systematic literature search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) to identify clinical studies that employed a form of radioimmunotherapy using alpha- or beta-emitting radioisotopes. The available literature on RIT in GBM and high-grade gliomas is presented and discussed. The results suggest that this promising treatment approach merits further investigation in future clinical studies.

多形性胶质母细胞瘤 (GBM) 或 IV 级星形细胞瘤是成人原发性脑肿瘤中诊断率最高的形式。放射免疫疗法 (RIT) 主要与常规疗法相结合，在当前的审查中被提出作为一种在 GBM 管理中具有高潜力的治疗策略。根据系统评价和荟萃分析的首选报告项目 (PRISMA) 进行了系统的文献检索，以确定采用一种使用 α 或 β 发射放射性同位素的放射免疫疗法形式的临床研究。介绍和讨论了关于 GBM 和高级别胶质瘤中 RIT 的可用文献。结果表明，这种有前景的治疗方法值得在未来的临床研究中进一步研究。