Cardiac fibrosis is a pathological process that presents a continuous overproduction of extracellular matrix (ECM) components in the myocardium, which negatively influences the progression of many cardiac diseases. Transforming growth factor β (TGFβ) is the main ligand that triggers the production of pro-fibrotic ECM proteins. In the cardiac fibrotic process, TGFβ and its canonical signaling mediators are tightly regulated at different levels as well as epigenetically. Cardiac fibroblasts are one of the most important TGFβ target cells activated after cardiac injury. TGFβ-driven fibroblast activation is subject to epigenetic modulation and contributes to the progression of cardiac fibrosis, mainly through the expression of pro-fibrotic molecules implicated in the disease. In this review, we describe epigenetic regulation related to canonical TGFβ signaling in cardiac fibroblasts.

心脏纤维化是一种病理过程，表现为心肌中细胞外基质 (ECM) 成分的持续过量产生，这对许多心脏病的进展产生负面影响。转化生长因子 β (TGFβ) 是触发促纤维化 ECM 蛋白产生的主要配体。在心脏纤维化过程中，TGFβ 及其典型信号传导介质在不同水平以及表观遗传上受到严格调节。心脏成纤维细胞是心脏损伤后激活的最重要的 TGFβ 靶细胞之一。TGFβ 驱动的成纤维细胞活化受到表观遗传调节，并有助于心脏纤维化的进展，主要是通过与疾病有关的促纤维化分子的表达。在本次审查中，