Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2021-06-10 , DOI: 10.1007/s13659-021-00314-z Jun Yin 1, 2 , Hong-Tao Zhu 1 , Man Zhang 1 , Dong Wang 1 , Chong-Ren Yang 1 , Ying-Jun Zhang 1, 3
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The extensive chemical investigation on the branches and leaves of Terminalia chebula var. tomentella (Combretaceae) led to the isolation of two new lignan glucosides with a furofuran skeleton, termitomenins F (1) and G (2). In addition, 19 known compounds including five lignan glucosides (3–7), six hydrolyzable tannins (8–13) and eight simple phenolics (14–21) were also identified. Their structures were determined by comprehensive spectroscopic analyses. It is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6, respectively, which were rarely found in plants. Nine known compounds, 6–9, 13, and 18–21, were procured from the titled plant for the first time, while 3–5, 10–12 and 14–17 were also found in the fruits. Notably, the known hydrolyzable tannins 8–13 exhibited stronger α-glucosidase inhibitory activities with IC50 values ranging from 0.10 to 3.12 μM, than the positive control, quercetin (IC50 = 9.38 ± 0.33 μM).
Graphic abstract
中文翻译：
Termitomenins F 和 G，来自榄仁树的两种新木脂素糖苷。 tomentella (库尔兹) CB Clarke
对榄仁树的枝叶进行了广泛的化学研究。 tomentella （Combretaceae）导致分离出两种具有呋喃呋喃骨架的新木脂素糖苷，termitomenins F ( 1 ) 和 G ( 2 )。此外，还鉴定出19种已知化合物，包括5种木酚素苷( 3-7 )、6种可水解单宁( 8-13 )和8种简单酚类( 14-21 )。它们的结构是通过综合光谱分析确定的。值得注意的是， 8和9是C-糖苷可水解单宁，其具有一个六羟基二苯酰基和一个五倍子酰基，分别连接到开链葡糖基C -1/ O -2/ O -3 和O -4/ O -6 上，其中在植物中很少发现。 9种已知化合物6-9、13和18-21是首次从该植物中提取，而3-5、10-12和14-17也在果实中发现。值得注意的是，已知的可水解单宁8 – 13比阳性对照槲皮素表现出更强的 α-葡萄糖苷酶抑制活性，IC 50值范围为 0.10 至 3.12 μM（IC 50 = 9.38 ± 0.33 μM）。
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