Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Conclusively, this study suggested that silencing of HOXA11-AS restrained proliferation, invasion, induced apoptosis of glioma cells, and repressed xenograft growth via modulating miR-124 expression and thus inhibited glioma progression.

我们的目的是阐明lncRNA HOXA11-AS（HOXA11-AS）对胶质瘤进展的调控，并探讨HOXA11-AS调节胶质瘤发生发展的机制。本研究证实了miR-124和HOXA11-AS对胶质瘤进展的调控作用。在此，HOXA11-AS 在神经胶质瘤中过表达，而 miR-124 表达不足。 miR-124的表达与HOXA11-AS的表达呈负相关。 HOXA11-AS 的沉默可抑制体外神经胶质瘤细胞的细胞增殖、侵袭并促进细胞凋亡。此外，抑制 HOXA11-AS 表达可抑制神经胶质瘤异种移植肿瘤的生长。 miR-124 的表达被起海绵作用的 HOXA11-AS 抑制。此外，miR-124敲低部分消除了HOXA11-AS下调在神经胶质瘤细胞中的抑制作用。总之，这项研究表明，HOXA11-AS 的沉默抑制了神经胶质瘤细胞的增殖、侵袭、诱导细胞凋亡，并通过调节 miR-124 表达抑制异种移植物生长，从而抑制神经胶质瘤进展。