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Interaction between the pulmonary stretch receptor and pontine control of expiratory duration
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-06-11 , DOI: 10.1016/j.resp.2021.103715
Edward J Zuperku 1 , Francis A Hopp 2 , Eckehard A E Stuth 3 , Astrid G Stucke 3
Affiliation  

Medial parabrachial nucleus (mPBN) neuronal activity plays a key role in controlling expiratory (E)-duration (TE). Pulmonary stretch receptor (PSR) activity during the E-phase prolongs TE. The aims of this study were to characterize the interaction between the PSR and mPBN control of TE and underlying mechanisms. Decerebrated mechanically ventilated dogs were studied. The mPBN subregion was activated by electrical stimulation via bipolar microelectrode. PSR afferents were activated by low-level currents applied to the transected central vagus nerve. Both stimulus-frequency patterns during the E-phase were synchronized to the phrenic neurogram; TE was measured. A functional mathematical model for the control of TE and extracellular recordings from neurons in the preBötzinger/Bötzinger complex (preBC/BC) were used to understand mechanisms. Findings show that the mPBN gain-modulates, via attenuation, the PSR-mediated reflex. The model suggested functional sites for attenuation and neuronal data suggested correlates. The PSR- and PB-inputs appear to interact on E-decrementing neurons, which synaptically inhibit pre-I neurons, delaying the onset of the next I-phase.



中文翻译:

肺牵张感受器与脑桥对呼气持续时间的控制之间的相互作用

内侧臂旁核 (mPBN) 神经元活动在控制呼气 (E) 持续时间 (TE) 中起关键作用。E 期的肺牵张受体 (PSR) 活动可延长 TE。本研究的目的是描述 TE 的 PSR 和 mPBN 控制之间的相互作用以及潜在机制。研究了去大脑机械通气的狗。mPBN 子区域通过双极微电极的电刺激被激活。PSR 传入由施加于横断的中央迷走神经的低水平电流激活。E 期的两种刺激频率模式均与膈神经图同步;测量了 TE。用于控制 TE 和 preBötzinger/Bötzinger 复合体 (preBC/BC) 中神经元的细胞外记录的功能数学模型用于理解机制。增益通过衰减调节 PSR 介导的反射。该模型提出了衰减的功能位点,并且神经元数据提出了相关性。PSR 和 PB 输入似乎与 E 递减神经元相互作用,后者突触抑制前 I 神经元,延迟下一个 I 期的开始。

更新日期:2021-06-18
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