Glioma is the most common type of primary tumor in the central nervous system, and the molecular mechanisms remain elusive. N-myc downstream-regulated gene (NDRG) family is reported to take part in the pathogenesis of various diseases, including some preliminary exploration in glioma. However, there has been no bioinformatics analysis of NDRG family in glioma yet. Herein, we focused on the expression changes of NDRGs with their value in predicting patients' prognoses, upstream regulatory mechanisms (DNA mutation, DNA methylation, transcription factors, and microRNA regulation) and gene enrichment analysis based on co-expressed genes with data from public databases. Furthermore, the expression pattern of NDRGs was verified by the paired glioma and peritumoral samples in our institute. It was suggested that NDRGs were differentially expressed genes in glioma. In particular, the lower expression of NDRG2 or NDRG4 could serve as a predictor of higher grade tumor and poorer prognosis. Also, NDRGs might play a crucial role in signal transduction, energy metabolism, and cross-talk among cells in glioma, under the control of a complex regulatory network. This study enables us to better understand the role of NDRGs in glioma and with further research, it may contribute to the development of glioma treatment.

中文翻译：

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基于生物信息学分析 N-myc 下游调控基因家族在胶质瘤中的作用

神经胶质瘤是中枢神经系统中最常见的原发性肿瘤类型，其分子机制尚不清楚。据报道，N-myc 下游调节基因 ( NDRG ) 家族参与了多种疾病的发病机制，包括对胶质瘤的一些初步探索。然而，目前还没有神经胶质瘤中NDRG家族的生物信息学分析。在此，我们重点研究了NDRGs的表达变化及其在预测患者预后方面的价值、上游调控机制（DNA 突变、DNA 甲基化、转录因子和 microRNA 调控）以及基于共表达基因的基因富集分析以及来自公共数据的数据。数据库。此外，NDRGs的表达模式经我院成对的胶质瘤和瘤周样本进行了验证。有人提出NDRGs是胶质瘤中差异表达的基因。特别是NDRG2或NDRG4的低表达可以作为较高级别肿瘤和较差预后的预测因子。此外，在复杂调控网络的控制下，NDRGs 可能在神经胶质瘤细胞之间的信号转导、能量代谢和串扰中发挥关键作用。这项研究使我们能够更好地了解NDRGs在神经胶质瘤中的作用，随着进一步研究，它可能有助于神经胶质瘤治疗的发展。