Continuous-flow diazotization of red base KD hydrochloride suspensions in a microreaction system,Reaction Chemistry & Engineering

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Continuous-flow diazotization of red base KD hydrochloride suspensions in a microreaction system
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-5-25 , DOI: 10.1039/d1re00075f
Fa-Jun Wang _{1,

2,

3,

4,

5} , An Chen _{1,

2,

3,

4,

5} , Si-da Ling _{1,

2,

3,

4,

5} , Jian-Hong Xu _{1,

2,

3,

4,

5}

Affiliation

In this work, a continuous-flow microreaction system has been developed to perform the diazotization reaction of red base KD hydrochloride in the form of a suspension solution. By investigating the effects of reaction temperature, reactant volume flow, red base KD concentration and reaction time on the diazotization reaction, the optimal reaction conditions were obtained. According to the solid–liquid reaction model, we found that the agglomeration of suspensions significantly affects the diazotization reaction due to the solid–liquid mass transfer process. Consequently, different red base KD hydrochloride suspensions were prepared under different conditions to explore the agglomeration phenomenon of the suspensions, and we observed that the crystal agglomeration could be prevented by optimizing the process of preparing the reaction suspensions. The results showed that the yield of the diazotization reaction using these optimized suspensions, which were prepared by introducing concentrated hydrochloric acid in three sequential additions of equal volume, could reach over 99% in 21.2 s at two different suspension concentrations (suspension concentration: 0.12 mol L⁻¹ and 0.15 mol L⁻¹).

中文翻译：

微反应系统中红碱 KD 盐酸盐悬浮液的连续流重氮化

在这项工作中，开发了一种连续流动的微反应系统，以悬浮液的形式进行红碱 KD 盐酸盐的重氮化反应。通过考察反应温度、反应物体积流量、红碱KD浓度和反应时间对重氮化反应的影响，得到了最佳反应条件。根据固-液反应模型，我们发现由于固-液传质过程，悬浮液的团聚显着影响重氮化反应。因此，在不同条件下制备了不同的红基KD盐酸盐悬浮液以探索悬浮液的团聚现象，我们观察到可以通过优化反应悬浮液的制备过程来防止晶体团聚。^-1和 0.15 mol L^-1 )。

更新日期：2021-06-11

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