ABSTRACT

Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2⁺ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2⁺ gene.

中文翻译：

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影响裂殖酵母寿命的sur2突变的鉴定

摘要

酵母是分析寿命机制的合适模型系统。在这项研究中，为了确定与按时间顺序排列的寿命有关的新因素，我们分离了一个按时间顺序排列的寿命长的突变体，并在sur2 ⁺基因中发现了一个错义突变，该基因编码裂变酵母中酿酒酵母鞘脂 C4-羟化酶的同源物。突变体的表征表明sur2功能的丧失导致按时间顺序排列的寿命延长。热量限制的影响是众所周知的延长寿命的信号，被认为取决于sur2 ⁺基因。