Abstract — Cramizol, an imidazole derivative, exhibits lipid-lowering and anti-atherogenic effects. In animals with acute hyperlipidemia induced by Triton WR-1339 cramizol reduced blood levels of cholesterol and triglycerides, and also the atherogenic index. Cramizol and the lipid-lowering drug fenofibrate demonstrated similar effectiveness as hypolipidemic agents. Cramizol also restored the expression of the Apoa1 gene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action.

中文翻译：

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Сramizol对实验性高脂血症大鼠ApoA1基因表达的影响

摘要 — Cramizol 是一种咪唑衍生物，具有降脂和抗动脉粥样硬化作用。在 Triton WR-1339 诱导的急性高脂血症动物中，cramizol 降低了血液中的胆固醇和甘油三酯水平，以及致动脉粥样硬化指数。Cramizol 和降脂药物非诺贝特显示出与降血脂药相似的功效。Cramizol 还可以将实验诱导的高脂血症大鼠中 Apoa1 基因的表达恢复到正常值。这可能是其降血脂和抗动脉粥样硬化作用的基础。