Gastric cancer is a malignant tumor with a poor prognosis. Therefore, it is important to search for molecules that play a vital role in the development, diagnosis, and treatment of this disease. Placenta-specific 1 (PLAC1) is one of the cancer-testis antigens; it plays an important role in both placental development and tumorigenesis. However, the role of PLAC1 in gastric cancer has not been fully investigated, and its underlying mechanism needs further study. We first explored the expression and clinical relevance of PLAC1 in gastric cancer and performed gene set enrichment analysis of PLAC1-related genes using online databases. Subsequently, we studied the function and mechanism of PLAC1 in gastric cancer cells through in vitro experiments. Our results showed that PLAC1 is highly expressed in gastric cancer, is associated with poor prognosis, and can promote gastric cancer cell proliferation through the AKT/GSK-3β/cyclin D1 signaling pathway. Moreover, we discovered that AKTi attenuates the effect of PLAC1. Our study further revealed the role and mechanism of PLAC1 in gastric cancer and suggested that this antigen might be a useful molecular marker for gastric cancer diagnosis, prognosis, and treatment.

中文翻译：

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胎盘特异性蛋白1通过AKT/GSK-3β/cyclin D1信号通路促进胃癌细胞增殖

胃癌是一种预后较差的恶性肿瘤。因此，寻找在这种疾病的发展、诊断和治疗中发挥重要作用的分子非常重要。胎盘特异性 1 (PLAC1) 是一种癌症睾丸抗原；它在胎盘发育和肿瘤发生中都起着重要作用。然而，PLAC1在胃癌中的作用尚未得到充分研究，其潜在机制有待进一步研究。我们首先探索了 PLAC1 在胃癌中的表达和临床相关性，并使用在线数据库对 PLAC1 相关基因进行了基因集富集分析。随后，我们通过体外实验研究了PLAC1在胃癌细胞中的功能和机制。我们的研究结果表明，PLAC1 在胃癌中高表达，与预后不良有关，并可通过AKT/GSK-3β/cyclin D1信号通路促进胃癌细胞增殖。此外，我们发现 AKTi 减弱了 PLAC1 的作用。我们的研究进一步揭示了PLAC1在胃癌中的作用和机制，提示该抗原可能是胃癌诊断、预后和治疗的有用分子标志物。