当前位置：
X-MOL 学术
›
Nanoscale Horiz.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Nanoprobe-mediated precise imaging and therapy of glioma
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2021-5-21 , DOI: 10.1039/d1nh00182e Tao Tang 1 , Baisong Chang 1 , Mingxi Zhang 1 , Taolei Sun 2
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2021-5-21 , DOI: 10.1039/d1nh00182e Tao Tang 1 , Baisong Chang 1 , Mingxi Zhang 1 , Taolei Sun 2
Affiliation
|
Gliomas are the most common primary brain tumors in adults, accounting for 80% of primary intracranial tumors. Due to the heterogeneous and infiltrating nature of malignant gliomas and the hindrance of the blood–brain barrier (BBB), it is very difficult to accurately image and differentiate the malignancy grade of gliomas, thus significantly influencing the diagnostic accuracy and subsequent surgery or therapy. In recent years, the rapid development of emerging nanoprobes has provided a promising opportunity for the diagnosis and treatment of gliomas. After rational component regulation and surface modification, functional nanoprobes could efficiently cross the BBB, target gliomas, and realize single-modal or multimodal imaging of gliomas with high clarity. Moreover, these contrast nanoagents could also be conjugated with therapeutic drugs and cure cancerous tissues at the same time. Herein, we focus on the design strategies of nanoprobes for effective crossing of the BBB, and introduce the recent advances in the precise imaging and therapy of gliomas using functional nanoprobes. Finally, we also discuss the challenges and future directions of nanoprobe-based diagnosis and treatment of gliomas.
中文翻译：
纳米探针介导的神经胶质瘤精确成像和治疗
胶质瘤是成人最常见的原发性脑肿瘤，占原发性颅内肿瘤的80%。由于恶性胶质瘤的异质性和浸润性以及血脑屏障（BBB）的障碍，很难准确地成像和区分胶质瘤的恶性程度，从而显着影响诊断的准确性和后续的手术或治疗。近年来，新兴纳米探针的快速发展为胶质瘤的诊断和治疗提供了广阔的前景。经过合理的成分调控和表面修饰，功能性纳米探针可以高效穿越血脑屏障，靶向胶质瘤，实现胶质瘤的单模态或多模态高清晰度成像。而且，这些对比纳米剂还可以与治疗药物结合，同时治愈癌组织。在此，我们专注于纳米探针有效穿越 BBB 的设计策略，并介绍使用功能性纳米探针精确成像和治疗胶质瘤的最新进展。最后，我们还讨论了基于纳米探针的胶质瘤诊断和治疗的挑战和未来方向。
更新日期：2021-06-10
中文翻译：
纳米探针介导的神经胶质瘤精确成像和治疗
胶质瘤是成人最常见的原发性脑肿瘤，占原发性颅内肿瘤的80%。由于恶性胶质瘤的异质性和浸润性以及血脑屏障（BBB）的障碍，很难准确地成像和区分胶质瘤的恶性程度，从而显着影响诊断的准确性和后续的手术或治疗。近年来，新兴纳米探针的快速发展为胶质瘤的诊断和治疗提供了广阔的前景。经过合理的成分调控和表面修饰，功能性纳米探针可以高效穿越血脑屏障，靶向胶质瘤，实现胶质瘤的单模态或多模态高清晰度成像。而且，这些对比纳米剂还可以与治疗药物结合，同时治愈癌组织。在此，我们专注于纳米探针有效穿越 BBB 的设计策略，并介绍使用功能性纳米探针精确成像和治疗胶质瘤的最新进展。最后，我们还讨论了基于纳米探针的胶质瘤诊断和治疗的挑战和未来方向。
京公网安备 11010802027423号