Topics in Current Chemistry ( IF 7.1 ) Pub Date : 2021-06-10 , DOI: 10.1007/s41061-021-00342-w Anmol Singh 1 , Pranjit Barman 1
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This review concentrates on recent developments in ruthenium Schiff bases, whose steric and electronic characteristics can be manipulated easily by selecting suitable condensing aldehydes or ketones and primary amines, and their metal complexes. Ruthenium metal-based complexes and Schiff base ligands are rapidly becoming conventionally considered for biological applications (antioxidant, anticancer, antimicrobial), in catalysis, in functional materials, in sensors, and as pigments for dyes. Ruthenium complexes exhibit a broad variety of activities concerning simple Schiff base ligands. This may be due to the octahedral bonding of both Ru(II) and Ru(III) complexes, which acquire an extended reservoir of a three-dimensional framework, providing the potential for an elevated degree of site selectivity for binding to their biological targets. This review provides an overview of this field, and intends to highlight both ligand design and synthetic methodology development, as well as significant applications of these metal complexes. In this review, we summarize our work on the development of ruthenium complexes, which was performed over the last few years.
Graphic Abstract
中文翻译：
席夫碱金属钌配合物的合成与应用研究进展
本综述重点关注钌席夫碱的最新发展，通过选择合适的缩合醛或酮和伯胺及其金属配合物，可以轻松控制其空间和电子特性。钌金属基络合物和席夫碱配体正迅速成为生物应用（抗氧化剂、抗癌、抗菌）、催化、功能材料、传感器和染料颜料的常规考虑。钌配合物表现出与简单席夫碱配体有关的多种活性。这可能是由于 Ru(II) 和 Ru(III) 复合物的八面体键合，它们获得了三维框架的扩展储层，为结合其生物靶标提供了更高程度的位点选择性的潜力。本综述概述了该领域，旨在强调配体设计和合成方法开发，以及这些金属配合物的重要应用。在这篇综述中，我们总结了我们在过去几年中进行的钌配合物开发工作。
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