This study examined developmental patterns of co-occurrent alcohol, marijuana, and other illicit drugs use during adolescence and the associated preadolescent risk factors in a longitudinal sample of 926 boys from low-socioeconomic, urban neighborhoods. Latent growth mixture modeling revealed six developmental patterns: non-/low-alcohol and non-illicit drug users (61% sample) and five polysubstance user-groups varying in severity based on onset, frequency and type of substances used. In comparisons with non-/low-users, several preadolescent risk factors were associated with increasing severity of polysubstance use. Higher sensation-seeking and lower anxiety were associated with all user-groups. Low self-esteem and family-related risk factors differentiated all user-groups from later-onset users. Higher impulsivity and school problems characterized early-onset and frequent polysubstance users. Impulsive sensation-seekers with lower anxiety and self-esteem cumulated a larger number and higher severity of risk factors and were at risk of early-onset frequent polysubstance use, emphasising the importance of indicated prevention for these high-risk boys.

本研究对 926 名来自低社会经济的城市社区的男孩的纵向样本，检查了青春期同时使用酒精、大麻和其他非法药物的发展模式以及相关的青春期前危险因素。潜在生长混合物模型揭示了六种发育模式：非/低酒精和非非法吸毒者（61% 的样本）和五个多物质使用者组，其严重程度因使用物质的发作、频率和类型而异。与非/低使用者相比，几个青春期前风险因素与多物质使用的严重程度增加有关。更高的感觉寻求和更低的焦虑与所有用户组相关。低自尊和与家庭相关的风险因素将所有用户组与晚发用户区分开来。较高的冲动性和学校问题的特点是早发和频繁使用多种物质。具有较低焦虑和自尊的冲动性感觉寻求者累积了更多和更严重的风险因素，并且有早发性频繁使用多种物质的风险，这强调了对这些高危男孩进行指示性预防的重要性。