Functional brain network topology across the menstrual cycle is estradiol dependent and correlates with individual well-being,Journal of Neuroscience Research

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Functional brain network topology across the menstrual cycle is estradiol dependent and correlates with individual well-being
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2021-06-10 , DOI: 10.1002/jnr.24898
Marianna Liparoti ₁ , Emahnuel Troisi Lopez ₁ , Laura Sarno ₂ , Rosaria Rucco _{1,

3} , Roberta Minino ₁ , Matteo Pesoli ₁ , Giuseppe Perruolo _{4,

5} , Pietro Formisano _{4,

5} , Fabio Lucidi ₆ , Giuseppe Sorrentino _{1,

3,

7} , Pierpaolo Sorrentino _{3,

8}

Affiliation

The menstrual cycle (MC) is a sex hormone-related phenomenon that repeats itself cyclically during the woman's reproductive life. In this explorative study, we hypothesized that coordinated variations of multiple sex hormones may affect the large-scale organization of the brain functional network and that, in turn, such changes might have psychological correlates, even in the absence of overt clinical signs of anxiety and/or depression. To test our hypothesis, we investigated longitudinally, across the MC, the relationship between the sex hormones and both brain network and psychological changes. We enrolled 24 naturally cycling women and, at the early-follicular, peri-ovulatory, and mid-luteal phases of the MC, we performed: (a) sex hormone dosage, (b) magnetoencephalography recording to study the brain network topology, and (c) psychological questionnaires to quantify anxiety, depression, self-esteem, and well-being. We showed that during the peri-ovulatory phase, in the alpha band, the leaf fraction and the tree hierarchy of the brain network were reduced, while the betweenness centrality (BC) of the right posterior cingulate gyrus (rPCG) was increased. Furthermore, the increase in BC was predicted by estradiol levels. Moreover, during the luteal phase, the variation of estradiol correlated positively with the variations of both the topological change and environmental mastery dimension of the well-being test, which, in turn, was related to the increase in the BC of rPCG. Our results highlight the effects of sex hormones on the large-scale brain network organization as well as on their possible relationship with the psychological state across the MC. Moreover, the fact that physiological changes in the brain topology occur throughout the MC has widespread implications for neuroimaging studies.

中文翻译：

整个月经周期的功能性脑网络拓扑结构依赖于雌二醇，并与个体幸福感相关

月经周期 (MC) 是一种与性激素相关的现象，在女性的生殖生命中周期性地重复。在这项探索性研究中，我们假设多种性激素的协调变化可能会影响大脑功能网络的大规模组织，并且反过来，这种变化可能具有心理相关性，即使没有明显的焦虑和临床症状和/ 或抑郁症。为了检验我们的假设，我们在整个 MC 中纵向调查了性激素与大脑网络和心理变化之间的关系。我们招募了 24 名自然骑自行车的女性，在 MC 的早期卵泡期、排卵期和黄体中期，我们进行了：(a) 性激素剂量，(b) 脑磁图记录以研究大脑网络拓扑结构，(c) 用于量化焦虑、抑郁、自尊和幸福感的心理问卷。我们发现，在排卵期，在 alpha 波段，大脑网络的叶分数和树层次结构减少，而右后扣带回 (rPCG) 的中介中心性 (BC) 增加。此外，雌二醇水平可以预测 BC 的增加。此外，在黄体期，雌二醇的变化与幸福感测试的拓扑变化和环境掌握维度的变化呈正相关，进而与rPCG的BC增加有关。我们的研究结果突出了性激素对大规模大脑网络组织的影响，以及它们与整个 MC 心理状态的可能关系。而且，

更新日期：2021-08-11

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