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Caged lipids for subcellular manipulation
Current Opinion in Chemical Biology ( IF 6.9 ) Pub Date : 2021-06-10 , DOI: 10.1016/j.cbpa.2021.04.012
Scotland Farley 1 , Aurélien Laguerre 1 , Carsten Schultz 1
Affiliation  

We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.



中文翻译:

用于亚细胞操作的笼状脂质

我们介绍了最近开发的通过光来控制活细胞脂质水平的策略。我们专注于导致亚细胞受限定位和激活的光可去除保护基团,并讨论替代技术。我们强调针对笼状脂质的细胞器靶向的发展,并讨论笼状基团的色正交性的最新进展以供未来应用。

更新日期:2021-06-10
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