Mesenchymal stromal cell (MSC)-derived exosomes play a promising role in regenerative medicine. Their trophic and immunomodulatory potential has made them a promising candidate for cardiac regeneration and repair. Numerous studies have demonstrated that MSC-derived exosomes can replicate the anti-inflammatory, anti-apoptotic, and pro-angiogenic and anti-fibrotic effects of their parent cells and are considered a substitute for cell-based therapies. In addition, their lower tumorigenic risk, superior immune tolerance, and superior stability compared with their parent stem cells make them an attractive option in regenerative medicine. The therapeutic effects of MSC-derived exosomes have consequently been evaluated for application in cardiac regeneration and repair. In this review, we summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.

间充质基质细胞（MSC）衍生的外泌体在再生医学中发挥着重要作用。它们的营养和免疫调节潜力使它们成为心脏再生和修复的有希望的候选者。大量研究表明，MSC 衍生的外泌体可以复制其亲代细胞的抗炎、抗凋亡、促血管生成和抗纤维化作用，被认为是细胞疗法的替代品。此外，与母体干细胞相比，它们的低致瘤风险、优越的免疫耐受性和优越的稳定性使它们成为再生医学的一个有吸引力的选择。因此，MSC 衍生的外泌体的治疗效果已被评估用于心脏再生和修复。在本次审查中，