A myriad of roles of dendritic cells in atherosclerosis,Clinical & Experimental Immunology

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A myriad of roles of dendritic cells in atherosclerosis
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-06-10 , DOI: 10.1111/cei.13634
Yanfang Zhao ₁ , Jing Zhang ₂ , Wenjie Zhang ₁ , Yuekang Xu ₁

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Atherosclerosis is an inflammatory disease with break-down of homeostatic immune regulation of vascular tissues. As a critical initiator of host immunity, dendritic cells (DCs) have also been identified in the aorta of healthy individuals and atherosclerotic patients, whose roles in regulating arterial inflammation aroused great interest. Accumulating evidence has now pointed to the fundamental roles for DCs in every developmental stage of atherosclerosis due to their myriad of functions in immunity and tolerance induction, ranging from lipid uptake, efferocytosis and antigen presentation to pro- and anti-inflammatory cytokine or chemokine secretion. In this study we provide a timely summary of the published works in this field, and comprehensively discuss both the direct and indirect roles of DCs in atherogenesis. Understanding the pathogenic roles of DCs during the development of atherosclerosis in vascular tissues would certainly help to open therapeutic avenue to the treatment of cardiovascular diseases.

中文翻译：

树突状细胞在动脉粥样硬化中的多种作用

动脉粥样硬化是一种炎症性疾病，破坏了血管组织的稳态免疫调节。作为宿主免疫的关键发起者，树突状细胞（DC）也已在健康个体和动脉粥样硬化患者的主动脉中被发现，其在调节动脉炎症中的作用引起了人们的极大兴趣。越来越多的证据表明，DC 在动脉粥样硬化的每个发育阶段都发挥着重要作用，因为它们在免疫和耐受诱导方面具有多种功能，从脂质摄取、细胞增多症和抗原呈递到促炎和抗炎细胞因子或趋化因子分泌。在本研究中，我们及时总结了该领域已发表的工作，并全面讨论了 DC 在动脉粥样硬化形成中的直接和间接作用。

更新日期：2021-06-10

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