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Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods
Bioactive Materials ( IF 18.0 ) Pub Date : 2021-06-10 , DOI: 10.1016/j.bioactmat.2021.05.044
Yuqiuhan Zhang 1 , Tycho Zimmermann 1 , Wolf-Dieter Mueller 1 , Frank Witte 1 , Florian Beuer 1 , Andreas Schwitalla 1
Affiliation  

Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant dentistry. The knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation material. Therefore, this work aimed to assess if the electrochemistry (EC) measurements of the corrosion process correlate with the surface features at various time points during the surface degradation, in order to describe the degradation process of Mg and Mg alloys more reliably, under the assumption that differences in EC behavior can be detected and related to specific patterns on the surface.

In this test setup, a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys (Mg2Ag, Mg4Ag, and Mg6Ag). Specimens were investigated using different circulating cell culture solutions as electrolytes, these were minimum essential medium (MEM), Hank's Balanced Salt Solution (HBSS), and MEM+ (MEM with added sodium hydrogen carbonate) at 37 °C. Open circuit potential measurements (OCP) over 30 min followed by cyclic polarization were performed. The electrochemistry data, including OCP, exchange current density and corrosion potential, were compared with visible changes at the surface during these treatments over time. The results show that the addition of silver (Ag) leads to a “standardization” of the degradation regardless of the selected test medium. It is currently difficult to correlate the visible microscopic changes with the data taken from the measurements. Therefore, further investigations are necessary.



中文翻译:

通过体外电化学方法探索 MgXAg 合金的降解行为

镁作为可生物降解的生物材料可用作种植牙的骨增强材料。有关生物降解过程的可预测性的知识至关重要,因为该过程需要与新骨的形成齐头并进,以逐渐取代增强材料。因此,这项工作旨在评估腐蚀过程的电化学 (EC) 测量值是否与表面降解过程中不同时间点的表面特征相关,以便在假设条件下更可靠地描述镁和镁合金的降解过程。可以检测到 EC 行为的差异并与表面上的特定模式相关。

在此测试设置中,使用特殊的光学室对镁和镁合金(Mg2Ag、Mg4Ag 和 Mg6Ag)进行电化学测量。使用不同的循环细胞培养溶液作为电解质对样本进行了研究,这些溶液是最低必需培养基 (MEM)、汉克平衡盐溶液 (HBSS) 和 MEM+(添加碳酸氢钠的 MEM),温度为 37 °C。进行了超过 30 分钟的开路电位测量 (OCP),然后进行了循环极化。将电化学数据(包括 OCP、交换电流密度和腐蚀电位)与这些处理过程中表面随时间的可见变化进行比较。结果表明,无论选择何种测试介质,银 (Ag) 的添加都会导致降解的“标准化”。目前很难将可见的微观变化与从测量中获取的数据相关联。因此,进一步的调查是必要的。

更新日期:2021-08-17
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