Purpose

The aim of this systematic review and meta-analysis was to define clinical indicator that predicts mediastinal lymph nodes metastasis (MLNM) in patients with Esophagogastric junction cancer (EGJC) to select patient population requiring esophagectomy.

Methods

A systematic and electronic search of several electronic databases was performed up to August 2020. Studies containing information on risk factors for MLNM in patients diagnosed with EJGC and who underwent curative surgery were included.

Results

Two predictors, including undifferentiated type (OR = 1.82, 95% CI = 1.07–3.10, p = 0.03) and esophageal invasion length (EIL) (OR = 10.95, 95% CI = 6.37–18.82, p < 0.00001) were identified as significant predictors for the risk of MLNM.

Conclusion

Knowledge of the associations of these clinicopathological features with MLNM can be useful in determining operative strategy for EGJC.

中文翻译：

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我们可以预测食管胃交界处癌的纵隔淋巴结转移吗？系统评价和荟萃分析的结果

目的

本系统评价和荟萃分析的目的是确定预测食管胃交界处癌 (EGJC) 患者纵隔淋巴结转移 (MLNM) 的临床指标，以选择需要食管切除术的患者人群。

方法

截至 2020 年 8 月，对几个电子数据库进行了系统和电子搜索。 研究包含了有关诊断为 EJGC 并接受治愈性手术的患者 MLNM 危险因素信息的研究。

结果

两个预测因子，包括未分化型（OR = 1.82，95% CI = 1.07–3.10，p  = 0.03）和食管浸润长度（EIL）（OR = 10.95，95% CI = 6.37–18.82，p  < 0.00001）被确定为MLNM 风险的重要预测因子。

结论

了解这些临床病理特征与 MLNM 之间的关系有助于确定 EGJC 的手术策略。