Aphasia, impairment of language after stroke or other neurological insult, is a common and often devastating condition that affects nearly every social activity and interaction. Behavioral speech and language therapy is the mainstay of treatment, although other interventions have been introduced to augment the effects of the behavioral therapy. In this narrative review, we discuss advances in aphasia therapy in the last 5 years and focus primarily on properly powered, randomized, controlled trials of both behavioral therapies and interventions to augment therapy for post-stroke aphasia. These trials include evaluation of behavioral therapies and computer-delivered language therapies. We also discuss outcome prediction trials as well as interventional trials that have employed noninvasive brain stimulation, or medications to augment language therapy. Supported by evidence from Phase III trials and large meta-analyses, it is now generally accepted that aphasia therapy can improve language processing for many patients. Not all patients respond similarly to aphasia therapy with the most severe patients being the least likely responders. Nevertheless, it is imperative that all patients, regardless of severity, receive aphasia management focused on direct therapy of language deficits, counseling, or both. Emerging evidence from Phase II trials suggests transcranial brain stimulation is a promising method to boost aphasia therapy outcomes.

中文翻译：

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目前治疗中风后失语症的方法。


失语症是中风或其他神经损伤后的语言障碍，是一种常见且往往具有破坏性的疾病，影响几乎所有社会活动和互动。行为言语和语言治疗是治疗的支柱，尽管已经引入了其他干预措施来增强行为治疗的效果。在这篇叙述性综述中，我们讨论了过去 5 年失语症治疗的进展，并主要关注针对中风后失语症增强治疗的行为疗法和干预措施的适当动力、随机、对照试验。这些试验包括行为疗法和计算机提供的语言疗法的评估。我们还讨论了结果预测试验以及采用非侵入性脑刺激或药物来增强语言治疗的介入试验。在 III 期试验和大型荟萃分析的证据支持下，现在普遍认为失语症治疗可以改善许多患者的语言处理。并非所有患者对失语症治疗的反应都相似，最严重的患者是最不可能出现反应的患者。然而，所有患者，无论严重程度如何，都必须接受失语症治疗，重点是语言缺陷的直接治疗、咨询或两者兼而有之。 II 期试验的新证据表明，经颅脑刺激是提高失语症治疗效果的一种有前途的方法。