Schistosoma mansoni worms are under a milieu of external and internal signaling pathways. The life-cycle stages are exposed to enormous stimuli within the mammalian and the snail hosts and as free-living stages in the fresh water. Furthermore, there is a unique interplay between the male and the female worms involving many stimuli from the male essential for full development of the female. PI3K/Akt/mTOR is an evolutionarily divergent signal transduction pathway universal to nearly every multicellular organism. This work reviews the Schistosoma mansoni PI3K/Akt/mTOR signal pathways and the involvement of the signal in the worms' physiology concerning the uptake of glucose, reproduction and survival. The inhibitors of the signal pathway used against Schistosoma mansoni were summarized. Given the importance of the PI3K/Akt/mTOR signal pathway, its inhibition could be a promising control strategy against schistosomiasis.

曼氏血吸虫蠕虫处于外部和内部信号通路的环境中。生命周期阶段暴露于哺乳动物和蜗牛宿主内的巨大刺激下，并作为淡水中的自由生活阶段。此外，雄性和雌性蠕虫之间存在独特的相互作用，涉及来自雄性的许多刺激，对于雌性的充分发育至关重要。PI3K/Akt/mTOR 是一种进化上发散的信号转导通路，几乎适用于所有多细胞生物。这项工作回顾了曼氏血吸虫PI3K/Akt/mTOR 信号通路以及该信号在蠕虫生理学中的参与，涉及葡萄糖的摄取、繁殖和存活。用于对抗曼氏血吸虫的信号通路抑制剂进行了总结。鉴于 PI3K/Akt/mTOR 信号通路的重要性，其抑制可能是一种有希望的控制血吸虫病的策略。