Abstract

Effects of methyltriclosan, a biodegradation product of the antimicrobial agent triclosan, on the functional parameters of rat liver mitochondria were studied. It was found that methyltriclosan inhibits the activity of complexes II and IV of the respiratory chain. This causes a decrease in the rate of oxygen consumption by mitochondria in states 3 and 3U_DNP. Methyltriclosan was shown to increase the rate of hydrogen peroxide production by rat liver mitochondria. In addition, methyltriclosan induces permeabilization of both mitochondrial membranes and the liposome membranes. Methyltriclosan, in contrast to triclosan, has a milder effect on organelles and their membranes. Possible mechanisms of methyltriclosan effects on mitochondria and liposomes are discussed.

中文翻译：

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甲基三氯生对离体大鼠肝线粒体功能和脂质体膜通透性的影响

摘要

研究了抗微生物剂三氯生的生物降解产物甲基三氯生对大鼠肝线粒体功能参数的影响。发现甲基三氯生抑制呼吸链复合物II和IV的活性。这导致状态 3 和 3U _{DNP 中}线粒体耗氧率降低。甲基三氯生被证明可以增加大鼠肝脏线粒体产生过氧化氢的速率。此外，甲基三氯生诱导线粒体膜和脂质体膜的透化。与三氯生相比，甲基三氯生对细胞器及其膜的影响较温和。讨论了甲基三氯生对线粒体和脂质体影响的可能机制。