Copper oxide-chitosan nanocomposite was synthesized simply via simple solution casting method and was characterized by different analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), and Thermogravimetric analysis (TGA). The copper oxide content in the prepared nanocomposite film was estimated from the Energy-dispersive X-ray spectroscopy (EDS) and the copper content in the sample was found to be 12.57 wt%. From the XRD pattern, the average particle size was calculated using Debye-Scherrer formula and was found to be 33.5 nm. The TGA curves showed that the thermal stability of the hybrid nanocomposite was found to be superior to the native CS, which is attributed to the existence of the thermally stable CuO. The chitosan/CuO nanocomposite has proven to be an excellent heterogeneous base catalyst for regioselective 1,3-dipolar cycloaddition of hydrazonoyl chlorides 1a-j with enamine 2 to give 1,3,4-trisubstituted pyrazoles 3a-j in excellent yields. The performance of the nanocomposite was optimized by varying several reaction conditions.

氧化铜-壳聚糖纳米复合材料通过简单的溶液浇铸法简单合成，并通过不同的分析技术进行表征，包括傅里叶变换红外光谱 (FTIR)、X 射线衍射 (XRD)、场发射扫描电子显微镜 (FESEM) 和热重分析分析（TGA）。由能量色散 X 射线光谱 (EDS) 估计所制备的纳米复合膜中的氧化铜含量，发现样品中的铜含量为 12.57 重量％。从XRD图谱中，使用Debye-Scherrer公式计算平均粒径，发现其为33.5nm。TGA 曲线表明，发现杂化纳米复合材料的热稳定性优于天然 CS，这归因于热稳定 CuO 的存在。1a-j与烯胺2以极好的收率得到 1,3,4-三取代的吡唑3a-j。通过改变几种反应条件来优化纳米复合材料的性能。