ABSTRACT Inulin is a linear fructose polymer which may affect small intestinal physiology. The effects of dietary level of two inulin types on morphology, contractility and proinflammatory cytokine gene expression in the small intestine of piglets were investigated. Fifty six piglets were divided into seven groups fed diets without inulin addition or with 1%, 2% or 3% of inulin with an average degree of polymerisation of 10 (IN10) or 23 (IN23). All diets were offered from day 10 of life for 40 d. Feeding IN10 diets did not affect villous height to crypt depth ratio in the duodenum, while in the jejunum the 2% IN10 diet increased it as compared to other groups. Jejunal muscle contractions induced by electrical field stimulation were impaired by the 2% and 3% IN10 diets. The ileal expression of interleukin-12p40 was decreased by the 2% IN10 diet. There was no effect of IN23 level on villous height to crypt depth ratio in any segment of the small intestine as well as on jejunal motility. The 2% and 3% IN23 diets decreased the jejunal expression of tumour necrosis factor-α. In conclusion, IN10 is more active in the small intestine than IN23. At the 2% dietary level, it increases absorptive area in the jejunum, but may slightly impair smooth muscle contractions.

中文翻译：

---

两种链长不同的菊粉对仔猪小肠形态、收缩力和促炎细胞因子基因表达的剂量依赖性影响

摘要 菊粉是一种线性果糖聚合物，可能影响小肠生理。研究了两种菊粉类型的日粮水平对仔猪小肠形态、收缩力和促炎细胞因子基因表达的影响。将 56 头仔猪分成 7 组，饲喂日粮不添加菊粉或添加 1%、2% 或 3% 的菊粉，平均聚合度为 10 (IN10) 或 23 (IN23)。从出生第 10 天开始提供所有饮食，持续 40 天。喂食 IN10 饮食不影响十二指肠中绒毛高度与隐窝深度的比率，而在空肠中，与其他组相比，2% IN10 饮食增加了它。由电场刺激引起的空肠肌肉收缩受到 2% 和 3% IN10 饮食的影响。2% IN10 饮食降低了白细胞介素-12p40 的回肠表达。IN23 水平对小肠任何节段的绒毛高度与隐窝深度比以及空肠运动没有影响。2% 和 3% IN23 饮食降低了肿瘤坏死因子-α 的空肠表达。总之，IN10 在小肠中比 IN23 更活跃。在 2% 的饮食水平下，它会增加空肠的吸收面积，但可能会轻微损害平滑肌收缩。