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Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-06-09 , DOI: 10.1111/cpr.13077
Yu Li 1, 2, 3 , Bingbing Wu 1, 2, 3 , Chengrui An 2, 3 , Deming Jiang 1, 2, 3 , Lin Gong 1, 2, 3 , Yanshan Liu 1, 2, 3 , Yixiao Liu 1, 2, 3 , Jun Li 2, 3 , Hongwei Ouyang 2, 3, 4, 5 , XiaoHui Zou 1, 2, 3
Affiliation  

The loss of LOXL1 expression reportedly leads to the prolapse of pelvic organs or to exfoliation syndrome glaucoma. Increasing evidence suggests that LOXL1 deficiency is associated with the pathogenesis of several other diseases. However, the characterization of the systemic functions of LOXL1 is limited by the lack of relevant investigative technologies.

中文翻译:

质谱流式细胞术和转录组学分析揭示了 Loxl1 缺陷引起的全身病理

据报道,LOXL1 表达的丧失会导致盆腔器官脱垂或剥脱综合征青光眼。越来越多的证据表明LOXL1缺乏与其他几种疾病的发病机制有关。然而,由于缺乏相关研究技术,对 LOXL1 系统功能的表征受到限制。
更新日期:2021-07-02
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