Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency,Cell Proliferation

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Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-06-09 , DOI: 10.1111/cpr.13077
Yu Li _{1,

2,

3} , Bingbing Wu _{1,

2,

3} , Chengrui An _{2,

3} , Deming Jiang _{1,

2,

3} , Lin Gong _{1,

2,

3} , Yanshan Liu _{1,

2,

3} , Yixiao Liu _{1,

2,

3} , Jun Li _{2,

3} , Hongwei Ouyang _{2,

3,

4,

5} , XiaoHui Zou _{1,

2,

3}

Affiliation

The loss of LOXL1 expression reportedly leads to the prolapse of pelvic organs or to exfoliation syndrome glaucoma. Increasing evidence suggests that LOXL1 deficiency is associated with the pathogenesis of several other diseases. However, the characterization of the systemic functions of LOXL1 is limited by the lack of relevant investigative technologies.

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