Abstract

The reactions of 1-isobutyl-4-(1-isocyanatoethyl)benzene with various amines and of 1-(4-isobutylphenyl)ethanamine with halogenated aromatic isocyanates gave a series of ureas containing an ibuprofen fragment in their structure. The yields of the target product yields were up to 95%. The synthesized ureas are potential multitarget inhibitors of soluble epoxide hydrolase (sEH) and cyclooxygenase (COX).

中文翻译：

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1,3-二取代脲及其含有多环片段的等排类似物的合成和性质：X. 1-[1-(4-异丁基苯基)乙基]-3-R-脲

摘要

1-异丁基-4-(1-异氰酸根合乙基)苯与各种胺和1-(4-异丁基苯基)乙胺与卤化芳族异氰酸酯的反应产生一系列在其结构中含有布洛芬片段的脲。目标产物收率高达95%。合成的尿素是可溶性环氧化物水解酶 (sEH) 和环氧合酶 (COX) 的潜在多靶点抑制剂。