Background: As the second most common female malignant tumor, cervical cancer is also one of the most preventable and avoidable cancers. The World Health Organization has launched a global plan to accelerate the elimination of cervical cancer. Therefore, in the era of postvaccine, the role of HPV subtypes in cervical precancerous lesions and cervical cancer that are not covered by vaccine should be further discussed. The purpose of this study was to explore the role of HPV subtypes not covered by the nine-valent vaccine in high-grade cervical precancerous lesions and cervical cancer. Materials and methods: A retrospective analysis was performed on the clinical data of 5220 patients with an HPV infection who were diagnosed and treated in the Department of Gynecology of Shanghai General Hospital between October 2016 and February 2020. In addition, the clinical characteristics of the biopsy results of 470 cases of cervical intraepithelial neoplasia (CIN) 2-3 and 205 cases of cervical squamous cell carcinoma were analyzed. Results: Among patients with HPV subtype infection not covered by the nine-valent vaccine, univariate analysis showed that compared with patients with CIN 2-3, age ≥ 50, not using condom and TCT reported as ASC-H were risk factors for cervical squamous cell carcinoma (P < 0.05). The detection rates of HPV subtype not covered by the nine-valent vaccine in CIN 2-3 and cervical squamous cell carcinoma patients were 7.23% and 6.34%, respectively. Conclusion: In patients with CIN 2-3 and cervical squamous cell carcinoma, the infection rates of HPV subtype not covered by the nine-valent vaccine were 7.23% and 6.34%, respectively. With the increasing popularity of the vaccine, the infection rates of the corresponding HPV subtype decreased; however, HPV subtype infection not covered by the nine-valent vaccine should not be ignored.

背景：宫颈癌作为女性第二常见的恶性肿瘤，也是最可预防和可避免的癌症之一。世界卫生组织启动了一项全球计划，以加速消除宫颈癌。因此，在疫苗后时代，HPV亚型在疫苗未覆盖的宫颈癌前病变和宫颈癌中的作用值得进一步探讨。本研究旨在探讨九价疫苗未覆盖的HPV亚型在高级别宫颈癌前病变和宫颈癌中的作用。材料和方法：回顾性分析2016年10月至2020年2月上海总医院妇科诊治的5220例HPV感染患者的临床资料。另外，470例活检结果的临床特征分析宫颈上皮内瘤变 (CIN) 2-3 和 205 例宫颈鳞状细胞癌。结果：在九价疫苗未覆盖的 HPV 亚型感染患者中，单因素分析显示，与 CIN 2-3、年龄≥50、未使用安全套和 TCT 报告为 ASC-H 的患者相比，是宫颈鳞状细胞癌的危险因素。细胞癌（P< 0.05)。九价疫苗未覆盖的HPV亚型在CIN 2-3和宫颈鳞癌患者中的检出率分别为7.23%和6.34%。结论： CIN 2-3和宫颈鳞癌患者中，九价疫苗未覆盖的HPV亚型感染率分别为7.23%和6.34%。随着疫苗的日益普及，相应HPV亚型的感染率下降；但不应忽视九价疫苗未涵盖的HPV亚型感染。