Designing multifunctional medical adhesives with strong adhesiveness under water is of great significance to achieve desirable therapeutic effects for promoting wound healing. However, its design is still challenging since most of existing hydrogel adhesive cannot work in wet environments. Here we proposed a tissue adhesive made from a combination of hydrogel matrix and nanocrystal fillers. The adhesion mechanism of this hydrogel adhesive relies on the absorption of interfacial water from tissue surfaces by hydrophilic hydrogel matrix, while the nanocrystals from the hydration process of calcium sulphoaluminate (CSA) contributes to strong cohesion. Subsequent noncovalent and covalent bonds between amine groups on tissue surfaces and catechol groups on polydopamine-intercalated silicate nanoflakes (PDA-Silicate) further improves the adhesion ability. The hydrogel adhesive with optimal compositions exhibited robust adhesiveness to different surfaces, with over 30 kPa of adhesive strength to porcine skin under water. Furthermore, chopped curcumin-loaded electrospun nanofibers were added into the precursor with optimized formulation to form nanofibers/hydrogel composite (NF-HG) in situ. The obtained NF-HG exhibited enhanced antibacterial activity, sustained drug release and good cytocompatibility. Taken together, this strategy may open new route to design versatile functional underwater adhesives.

设计水下附着力强的多功能医用胶粘剂对于达到理想的促进伤口愈合的治疗效果具有重要意义。然而，它的设计仍然具有挑战性，因为大多数现有的水凝胶粘合剂不能在潮湿环境中工作。在这里，我们提出了一种由水凝胶基质和纳米晶体填料组合制成的组织粘合剂。这种水凝胶粘合剂的粘附机制依赖于亲水性水凝胶基质从组织表面吸收界面水，而硫铝酸钙 (CSA) 水合过程中的纳米晶体有助于强内聚力。随后组织表面上的胺基团与聚多巴胺插层硅酸盐纳米片（PDA-Silicate）上的儿茶酚基团之间的非共价和共价键进一步提高了粘附能力。具有最佳组成的水凝胶粘合剂对不同表面表现出强大的粘合性，对水下猪皮肤的粘合强度超过30 kPa。此外，将切碎的负载姜黄素的电纺纳米纤维添加到具有优化配方的前体中以形成纳米纤维/水凝胶复合材料（NF-HG）就地。获得的NF-HG表现出增强的抗菌活性、持续的药物释放和良好的细胞相容性。综上所述，该策略可能为设计多功能功能性水下粘合剂开辟新途径。