The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the confirmed patients impaired with significant complications, including multi-organ failure. Acute respiratory distress imposed by SARS-CoV-2 largely results from an aggravated cytokine storm and deregulated immune response. The forkhead box O (FoxO) transcription factors are reported to play a significant role in maintaining normal cell physiology by regulating survival, apoptosis, oxidative stress, development and maturation of T and B lymphocytes, secretion of inflammatory cytokines, etc. We propose a potent anti-inflammatory approach based on activation of the FoxO as an attractive strategy against the novel coronavirus. This regime will be focused on restoring redox and inflammatory homeostasis along with repair of the damaged tissue, activation of lymphocyte effector and memory cells. Repurposing FoxO activators as a means to alleviate the inflammatory burst following SARS-CoV-2 infection can prove immensely valuable in the ongoing pandemic and provide a reliable groundwork for enriching our repertoire of antiviral modalities for any such complication in the future. Altogether, our review highlights the possible efficacy of FoxO activation as a novel arsenal for clinical management of COVID-19.

COVID-19 大流行在全球范围内造成了前所未有的社会破坏。感染者可能会出现轻度至重度症状，近 20% 的确诊患者会出现严重并发症，包括多器官衰竭。SARS-CoV-2 引起的急性呼吸窘迫主要是由于细胞因子风暴加剧和免疫反应失调所致。据报道，叉头框 O (FoxO) 转录因子通过调节存活、细胞凋亡、氧化应激、T 和 B 淋巴细胞的发育和成熟、炎性细胞因子的分泌等，在维持正常细胞生理学方面发挥重要作用。我们提出了一种有效的基于 FoxO 激活的抗炎方法是对抗新型冠状病毒的一种有吸引力的策略。该方案将侧重于恢复氧化还原和炎症稳态以及修复受损组织、激活淋巴细胞效应器和记忆细胞。重新利用 FoxO 激活剂作为减轻 SARS-CoV-2 感染后炎症爆发的一种手段，可以证明在持续的大流行中具有巨大的价值，并为丰富我们未来应对任何此类并发症的抗病毒方式提供可靠的基础。总而言之，我们的综述强调了 FoxO 激活作为 COVID-19 临床管理的新型武器库的可能功效。重新利用 FoxO 激活剂作为减轻 SARS-CoV-2 感染后炎症爆发的一种手段，可以证明在持续的大流行中具有巨大的价值，并为丰富我们未来应对任何此类并发症的抗病毒方式提供可靠的基础。总而言之，我们的综述强调了 FoxO 激活作为 COVID-19 临床管理的新型武器库的可能功效。重新利用 FoxO 激活剂作为减轻 SARS-CoV-2 感染后炎症爆发的一种手段，可以证明在持续的大流行中具有巨大的价值，并为丰富我们未来应对任何此类并发症的抗病毒方式提供可靠的基础。总而言之，我们的综述强调了 FoxO 激活作为 COVID-19 临床管理的新型武器库的可能功效。