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Generic nature of the condensed states of proteins
Nature Cell Biology ( IF 17.3 ) Pub Date : 2021-06-09 , DOI: 10.1038/s41556-021-00697-8
Monika Fuxreiter 1, 2 , Michele Vendruscolo 3
Affiliation  

Proteins undergoing liquid–liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the native state and the amyloid state. Here we discuss the generic nature of the liquid-like and solid-like condensed states, and describe a wide variety of biological functions conferred by these condensed states.



中文翻译:

蛋白质凝聚态的一般性质

正在以越来越快的速度发现进行液-液相分离的蛋白质。由于在细胞中存在的高浓度下,大多数蛋白质预计会形成液体凝聚态,因此应将这种状态与天然状态和淀粉样蛋白状态一起视为蛋白质的基本状态。在这里,我们讨论了类液体和类固体凝聚态的一般性质,并描述了这些凝聚态赋予的各种生物学功能。

更新日期:2021-06-09
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