Although olfactory disorders (OD) are among the most significant symptoms of COVID-19, recovery time from COVID-19-related OD and their consequences on the quality of life remain poorly documented. We investigated the characteristics and behavioral consequences of COVID-19-related OD using a large-scale study involving 3111 French respondents (78% women) to an online questionnaire over a period of 9 months covering different epidemic waves (from 8 April 2020 to 13 January 2021). In the patients who subjectively recovered from COVID-19-related OD (N = 609), recovery occurred on average after 16 days and most of the time within 1 month (“normal” recovery range); 49 subjectively recovered in 1–2.5 months, and several cases took up to 6.5 months. Among the patients with ongoing OD (N = 2502), 974 were outside the “normal” recovery range (persistent OD) and reported OD for 1–10 months. Developing a persistent OD was more likely with increasing age and in women and was more often associated with parosmia and phantosmia. The deleterious impact of COVID-19-related OD on the quality of life was significantly aggravated by OD duration and was more pronounced in women. Because persistent OD is not infrequent after COVID-19, has deleterious consequences on the quality of life, and receives few solutions from the health practitioners, it would be beneficial to implement screening and treatment programs to minimize the long-term behavioral consequences of COVID-19-related OD.

中文翻译：

---

从 COVID-19 相关的嗅觉障碍和生活质量中恢复：来自观察性在线研究的见解

尽管嗅觉障碍 (OD) 是 COVID-19 最显着的症状之一，但与 COVID-19 相关的 OD 的恢复时间及其对生活质量的影响仍然鲜有记载。我们使用一项涉及 3111 名法国受访者（78% 女性）的大规模研究调查了 COVID-19 相关 OD 的特征和行为后果，该研究在 9 个月内进行了涵盖不同流行浪潮（从 2020 年 4 月 8 日至 13 日）的在线问卷调查2021 年 1 月）。在从 COVID-19 相关 OD 中主观恢复的患者（N = 609）中，平均在 16 天后恢复，大部分时间在 1 个月内恢复（“正常”恢复范围）；49 例在 1-2.5 个月内主观康复，部分病例长达 6.5 个月。在持续 OD 的患者中（N = 2502），974 人超出“正常”恢复范围（持续 OD）并报告 OD 持续 1-10 个月。随着年龄的增长和女性更容易出现持续性 OD，并且更常与嗅觉异常和幻觉有关。OD 持续时间显着加剧了 COVID-19 相关 OD 对生活质量的有害影响，并且在女性中更为明显。由于持续性 OD 在 COVID-19 后并不少见，对生活质量产生有害影响，并且从卫生从业者那里得到的解决方案很少，因此实施筛查和治疗计划以尽量减少 COVID-19 的长期行为后果将是有益的。 19 相关 OD。OD 持续时间显着加剧了 COVID-19 相关 OD 对生活质量的有害影响，并且在女性中更为明显。由于持续性 OD 在 COVID-19 后并不少见，对生活质量产生有害影响，并且从卫生从业者那里得到的解决方案很少，因此实施筛查和治疗计划以尽量减少 COVID-19 的长期行为后果将是有益的。 19 相关 OD。OD 持续时间显着加剧了 COVID-19 相关 OD 对生活质量的有害影响，并且在女性中更为明显。由于持续性 OD 在 COVID-19 后并不少见，对生活质量产生有害影响，并且从卫生从业者那里得到的解决方案很少，因此实施筛查和治疗计划以尽量减少 COVID-19 的长期行为后果将是有益的。 19 相关 OD。