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Genome profiling of fluoroquinolone-resistant uropathogenic Escherichia coli isolates from Brazil
Brazilian Journal of Microbiology ( IF 2.1 ) Pub Date : 2021-06-08 , DOI: 10.1007/s42770-021-00513-3
Patrick da Silva 1 , Bruna C Lustri 1 , Ivana Giovannetti Castilho 2 , Adriano Martison Ferreira 3 , Rodrigo T Hernandes 2 , Mark A Schembri 4 , Cristiano G Moreira 1
Affiliation  

Urinary tract infections (UTIs) are a major public health concern in both community and hospital settings worldwide. Uropathogenic Escherichia coli (UPEC) is the main causative agent of UTI and increasingly associated with antibiotic resistance. Herein, we report the draft genome sequence of 9 fluoroquinolone-resistant UPEC isolates from Brazil and examine selected major phenotypic features, such as antimicrobial resistance profile, phylogroup, serotype, sequence type (ST), virulence genes, and resistance marks. Besides the quinolone resistance, beta-lactams, ESBL production, aminoglycosides, and tetracycline resistance were observed. High prevalence of 20 virulence genes was detected in all isolates, such as those encoding type 1 fimbriae, acid tolerance system, and hemolysin E, particularly within E. coli B2 phylogroup, as ST131 and ST1193 strains, among other genomic analyses as genomic islands, resistance plasmids, and integron identification.



中文翻译:

来自巴西的耐氟喹诺酮类尿路致病性大肠杆菌的基因组分析

尿路感染 (UTI) 是全球社区和医院环境中的主要公共卫生问题。尿路致病性大肠杆菌( UPEC )是尿路感染的主要病原体,并且与抗生素耐药性越来越相关。在此,我们报告了来自巴西的 9 个耐氟喹诺酮类 UPEC 分离株的基因组序列草图,并检查了选定的主要表型特征,例如抗菌素耐药性概况、系统群、血清型、序列类型 (ST)、毒力基因和耐药性标记。除了喹诺酮类耐药外,还观察到β-内酰胺类、ESBL 产生、氨基糖苷类和四环素耐药性。在所有分离株中检测到 20 个毒力基因的高流行率,例如编码 1 型菌毛、耐酸系统和溶血素 E 的毒力基因,特别是在大肠杆菌B2 系统群,如 ST131 和 ST1193 菌株,以及其他基因组分析,如基因组岛、抗性质粒和整合子鉴定。

更新日期:2021-06-09
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