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A brief overview about the use of different bioactive liposome-based drug delivery systems in Peritoneal Dialysis and some other diseases
Nano Express ( IF 2.7 ) Pub Date : 2021-05-13 , DOI: 10.1088/2632-959x/abfdd1
Sandeep Kumar Singh , Umesh Kumar , Anupam Guleria , Dinesh Kumar

Peritoneal dialysis (PD) is a promising way of treatment used for patients suffering from End-Stage Renal Failure (ESRF). Liposomes are nanocarriers comprised of lipid bilayers encapsulating an aqueous core. Liposomes are extensively used as drug delivery systems and several liposomal nanomedicines have been approved for clinical applications. Nanomedicine constitutes a new direction in peritonitis prevention using peritoneal dialysis (PD). In case of PD; there is a more risk of bacterial infection in the peritoneal cavity along with subcutaneous tunnel and catheter existing site. These infections are the most common complications associated with prolonged peritoneal dialysis (PD) therapy. To prevent such complications, patients used to treat with suitable antibiotic. Nanocarriers consist of assembly of nano-sized vehicles planned to deliver encapsulated/loaded bioactive(s) to the specific target (tissues or organs) and have provided prominent improved therapeutic efficacy for PD patients. The advantage of bioactive loaded nanocarrier has the efficient capacity to deliver at target specific site in PD. This review focuses mainly on the current use of different liposomal encapsulated bioactive compounds in drug delivery systems in the case of PD and other human diseases and briefly highlights the importance and use of different liposomal encapsulated antimicrobial agents to improve the PD technique.



中文翻译:

关于不同生物活性脂质体给药系统在腹膜透析和其他一些疾病中的应用的简要概述

腹膜透析 (PD) 是一种很有前景的治疗方法,用于治疗终末期肾功能衰竭 (ESRF) 的患者。脂质体是由包裹水性核心的脂质双层组成的纳米载体。脂质体被广泛用作药物递送系统,并且几种脂质体纳米药物已被批准用于临床应用。纳米医学构成了使用腹膜透析 (PD) 预防腹膜炎的新方向。在 PD 的情况下;腹腔内以及皮下隧道和导管现有部位存在更大的细菌感染风险。这些感染是与长期腹膜透析 (PD) 治疗相关的最常见并发症。为了预防此类并发症,患者过去常常使用合适的抗生素进行治疗。纳米载体由纳米尺寸的载体组成,计划将封装/装载的生物活性物质输送到特定目标(组织或器官),并为 PD 患者提供显着改善的治疗效果。生物活性负载纳米载体的优势在于具有在 PD 中特定目标位点的有效递送能力。本综述主要关注目前在 PD 和其他人类疾病的情况下,不同脂质体封装的生物活性化合物在药物递送系统中的使用,并简要强调了不同脂质体封装的抗菌剂在改进 PD 技术方面的重要性和用途。生物活性负载纳米载体的优势在于具有在 PD 中特定目标位点的有效递送能力。本综述主要关注目前在 PD 和其他人类疾病的情况下,不同脂质体封装的生物活性化合物在药物递送系统中的使用,并简要强调了不同脂质体封装的抗菌剂在改进 PD 技术方面的重要性和用途。生物活性负载纳米载体的优势在于具有在 PD 中特定目标位点的有效递送能力。本综述主要关注目前在 PD 和其他人类疾病的情况下,不同脂质体封装的生物活性化合物在药物递送系统中的使用,并简要强调了不同脂质体封装的抗菌剂在改进 PD 技术方面的重要性和用途。

更新日期:2021-05-13
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