Adherence to antiretroviral therapy (ART) remains an important factor in HIV prevention and treatment efforts. We explored the individual and environmental factors influencing antiretroviral adherence among PLWH in Ghana. This study used 20 semi-structured in-depth interviews and three focus group discussions (FGD) involving 29 PLWH attending one of three antiretroviral clinics. Thematic analysis covered experiences of PLWH clinic visits, knowledge, attitudes, self-efficacy related to ART adherence, psychological wellbeing and stigma. The findings suggest that both individual and environmental factors including treatment outcome, coping skills, disclosure, self-regulation, healthcare-provider interaction, family and partner support, organization of ART clinics, stigma, and transportation cost influenced treatment adherence. Interventions that empower PLWH and reduce HIV-related stigma in the community will most likely support antiretroviral adherence. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.

中文翻译：

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加纳 HIV 感染者抗逆转录病毒依从性影响因素的定性分析

坚持抗逆转录病毒疗法 (ART) 仍然是 HIV 预防和治疗工作的重要因素。我们探讨了影响加纳 PLWH 抗逆转录病毒依从性的个人和环境因素。本研究使用了 20 次半结构化深度访谈和 3 次焦点小组讨论 (FGD)，涉及 29 名感染者参加了三个抗逆转录病毒诊所之一。主题分析涵盖 PLWH 就诊经历、知识、态度、与 ART 依从性相关的自我效能、心理健康和耻辱感。研究结果表明，个人和环境因素，包括治疗结果、应对技巧、披露、自我调节、医疗保健提供者的互动、家庭和合作伙伴的支持、ART 诊所的组织、耻辱感和交通成本都会影响治疗依从性。赋予 PLWH 权力并减少社区中与 HIV 相关的污名化的干预措施很可能会支持抗逆转录病毒药物的依从性。请参阅补充材料部分以查找本文的社区和社会影响声明。