Ulcerative colitis is a form of inflammatory bowel disease that is characterized by acute and chronic inflammation. The aim of this work was to evaluate the efficacy of hydroethanolic extract of Maesa lanceolata leaves on acetic acid-induced colitis in rats. Colitis was induced by rectal administration of 1 mL of acetic acid (4%) in 25 male rats except the normal control group which received distilled water after 18 h of fasting followed by Ketamine (50 mg/kg)/Valium (10 mg/kg) anesthesia. Five hours later, the normal control and the negative control received distilled water, the positive control received prednisolone (5 mg/kg) and the three test groups received extract at 100, 200 and 400 mg/kg bw for eight days. During treatment, rectal temperature, the number and quality of the stools, and changes in body weight were assessed. At the end of the treatment, the animals were sacrificed, blood, colon, liver and spleen were collected for evaluation of hematological, inflammatory, antioxidant and histological parameters. Rectal temperature and the number of diarrheal, mucus and bloody stools were significantly reduced (P < 0.01) during treatment in the test and positive control groups with an increase in body weight change. The extract significantly (P < 0.01) reduced myeloperoxidase, TNF-α, interleukin 6, NO and MDA levels and significantly (P < 0.01) increased SOD levels, of GSH and catalase activity in the colon and blood. This extract also increased (P < 0.01) levels of red blood cells, hemoglobin, hematocrit, total white blood cells and blood platelets, prevented leukocyte infiltration in the liver and colon.

溃疡性结肠炎是一种炎症性肠病，其特征是急性和慢性炎症。这项工作的目的是评估Maesa lanceolata的水乙醇提取物的功效对醋酸诱导的大鼠结肠炎的叶子。25 只雄性大鼠经直肠给药 1 mL 醋酸 (4%) 诱发结肠炎，但正常对照组在禁食 18 小时后给予蒸馏水，然后给予氯胺酮 (50 mg/kg)/安定 (10 mg/kg) ) 麻醉。五小时后，正常对照和阴性对照接受蒸馏水，阳性对照接受泼尼松龙（5 毫克/千克），三个试验组接受 100、200 和 400 毫克/千克体重的提取物，持续 8 天。在治疗期间，评估直肠温度、粪便的数量和质量以及体重的变化。在治疗结束时，处死动物，收集血液、结肠、肝脏和脾脏用于评价血液学、炎症、抗氧化和组织学参数。P  < 0.01) 试验组和阳性对照组治疗期间体重变化增加。该提取物显着 ( P  < 0.01) 降低髓过氧化物酶、TNF-α、白细胞介素 6、NO 和 MDA 水平，并显着 ( P  < 0.01) 增加 SOD 水平、结肠和血液中的 GSH 和过氧化氢酶活性。该提取物还增加了 ( P  < 0.01) 红细胞、血红蛋白、血细胞比容、总白细胞和血小板的水平，防止了肝脏和结肠中的白细胞浸润。