Objective. To compare the cytology quality of ultrasound-guided fine-needle biopsy in thyroid nodules with 22-, 23-, and 25-gauge (G) needles prospectively. Methods. A total of 240 consecutive nodules underwent ultrasound-guided fine-needle aspiration (USG-FNA) and 240 nodules underwent ultrasound-guided fine-needle capillary (USG-FNC) were included in this prospective study from October 2014 to February 2016. Each nodule was sampled using 22 G, 23 G, and 25 G needle according to designed orders, and 1240 smears were finally obtained. Cytology quality was scored by a cytologist blinded to needle selection. Results. In USG-FNA, the average scores and standard deviations were for 25 G needles, for 23 G needles, and for 22 G needles. In USG-FNC, the average scores and standard deviations of each group were for 25 G, for 23 G, and for 22 G needles. The specimen quality scores of 25 G group were significantly higher than that of 23 G group () in both USG-FNA and USG-FNC. However, the differences were not statistically significant in nondiagnostic rate using different gauge of needles ( for all). Conclusions. 25 G needles obtained the highest scores of sample quality in thyroid FNA and FNC comparing with 22 G and 23 G needles. 25 G needle should be first choice of thyroid FNA and FNC in routine work.

中文翻译：

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22、23 和 25 号针在甲状腺结节中超声引导细针细胞学质量的比较

客观。前瞻性比较超声引导下甲状腺结节细针活检与 22、23 和 25 号 (G) 针的细胞学质量。方法。从 2014 年 10 月到 2016 年 2 月，这项前瞻性研究共纳入 240 个连续结节接受超声引导下细针穿刺 (USG-FNA) 和 240 个结节接受超声引导下细针毛细血管 (USG-FNC)。每个结节根据设计顺序分别使用22G、23G、25G针头进行取样，最终获得1240张涂片。细胞学质量由不知道针选择的细胞学家评分。结果。在 USG-FNA 中，平均分和标准差分别为对于 25 G 针头，用于 23 G 针头，以及适用于 22 G 针头。在 USG-FNC 中，各组的平均分和标准差分别为对于 25 G，对于 23 G，以及适用于 22 G 针头。25G组标本质量评分显着高于23G组（)在 USG-FNA 和 USG-FNC 中。然而，使用不同规格的针头的非诊断率差异无统计学意义（对所有人）。结论。与 22 G 和 23 G 针相比，25 G 针在甲状腺 FNA 和 FNC 中的样本质量得分最高。25G针应作为甲状腺FNA和FNC在日常工作中的首选。