Background and study aims Eosinophilic oesophagitis (EoE) is a common disease with a significant impact on physical health and quality of life (QoL). Outcomes and management vary widely, with no agreed UK national guideline. This paper aims to describe an up-to-date description of demographics, clinical spectrum and outcomes for paediatric and adult patients with EoE from the North East of England between 2016 and 2019. Patients and methods Patients from two large University Hospitals and the specialist paediatric hospital for the North East of England with histologically or clinically confirmed EoE were included in this analysis. Data were collected retrospectively via electronic patient records. Remission was defined as either the resolution of symptoms or improvement on histology. Results Data were collected on 74 paediatric and 59 adult patients. Dysphagia was the most common presenting symptom in both groups, accounting for 51%–84% of all presentations. Proton pump inhibitors and dietary manipulation were the most common therapies associated with remission in children (95% of those achieving remission), whereas the use of swallowed topical steroids was more prevalent in the treatment of adults (55% achieving remission). Conclusions EoE is a complex disease and poses significant challenges. Outcomes vary widely and need to be tailored to individual patient groups. Dietary manipulation plays a major role in treatment for EoE, but this is likely to be challenging for patients, especially children. Future work should continue to assess the outcomes in EoE, including on QoL and potential novel targeted therapies. All data relevant to the study are included in the article or uploaded as supplemental information.

中文翻译：

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2016 年至 2019 年英格兰东北部儿童和成人嗜酸性食管炎的临床谱

背景和研究目的 嗜酸性食管炎（EoE）是一种常见疾病，对身体健康和生活质量（QoL）有显着影响。结果和管理差异很大，没有商定的英国国家指南。本文旨在描述 2016 年至 2019 年间来自英格兰东北部的 EoE 儿科和成人患者的人口统计、临床谱和结果的最新描述。患者和方法 来自两家大型大学医院和专科儿科的患者英格兰东北部有组织学或临床证实 EoE 的医院被纳入该分析。通过电子病历回顾性收集数据。缓解被定义为症状的消退或组织学的改善。结果 收集了 74 名儿童和 59 名成人患者的数据。吞咽困难是两组中最常见的症状，占所有症状的 51%–84%。质子泵抑制剂和饮食控制是与儿童缓解相关的最常见疗法（95% 的儿童实现缓解），而口服局部类固醇的使用在成人治疗中更为普遍（55% 实现缓解）。结论 EoE 是一种复杂的疾病，并带来重大挑战。结果差异很大，需要针对个体患者群体进行调整。饮食控制在 EoE 的治疗中起着重要作用，但这对患者，尤其是儿童来说可能具有挑战性。未来的工作应继续评估 EoE 的结果，包括生活质量和潜在的新型靶向治疗。