The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.

中文翻译：

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不同剂量和频率的特立帕肽给药在去卵巢大鼠和猴子中引起的骨层状和骨胶原线性的定量分析

在包括人类在内的哺乳动物中观察到骨的层状结构，它赋予生物力学刚性以支持宿主生物体。因此，必须开发一种定量分析来评估骨的层状结构，这对于抗骨质疏松药物的药理学评估特别有用。本研究将当前用于半自动识别荧光信号的系统应用于分析用特立帕肽 (TPTD) 处理的大鼠和猴子标本的未脱钙骨切片。我们对骨形成模式和胶原拓扑结构的分析表明，TPTD 增强了骨层状和骨胶原线性，这可能与胶原交联的恢复有关，从而赋予骨刚性。