Canine mammary carcinoma (CMC) is the most common type of neoplasm in intact female dogs. While a previous study in Western countries validated the 2011 classification as an independent prognostic indicator in CMC, its role in CMC prognostication in Asian countries such as Korea remains unclear. In the present study, we estimate the survival rates in CMC types defined by the 2011 classification, elucidate the prognostic significance of the histological subtype and grade and that of the lymphatic invasion status in CMC, and validate the 2011 classification as an independent prognostic indicator in a large cohort of CMCs (excluding cases of multicentric CMCs). A total of 155 CMC cases retrieved from archived formalin-fixed, paraffin-embedded tissues, along with 2-year follow-up data, were retrospectively analysed. A significant association was found between the histological subtype of the 2011 classification and the tumour-specific survival. Carcinosarcoma, adenosquamous carcinoma and anaplastic carcinoma subtypes were associated with the poorest prognosis. Dogs with comedocarcinoma and solid carcinoma followed a disease course that was more aggressive than that observed in dogs with a carcinoma arising in a benign mixed tumour. Moreover, age, histological grade and lymphatic invasion status significantly correlated with tumour-specific survival in univariate analysis. In multivariate analysis, histological subtype, age and lymphatic invasion status remained independent prognostic factors for CMC.

犬乳癌 (CMC) 是完整母犬中最常见的肿瘤类型。虽然之前在西方国家的一项研究证实了 2011 年分类作为 CMC 的独立预后指标，但其在韩国等亚洲国家的 CMC 预后中的作用仍不清楚。在本研究中，我们估计了 2011 年分类定义的 CMC 类型的存活率，阐明了组织学亚型和分级以及 CMC 中淋巴浸润状态的预后意义，并验证了 2011 年分类作为独立预后指标一大群 CMC（不包括多中心 CMC 的情况）。回顾性分析了从存档的福尔马林固定石蜡包埋组织中检索到的 155 例 CMC 病例以及 2 年的随访数据。发现 2011 年分类的组织学亚型与肿瘤特异性存活率之间存在显着关联。癌肉瘤、腺鳞癌和间变性癌亚型预后最差。患有粉刺癌和实体癌的狗的病程比在患有良性混合肿瘤的癌的狗中观察到的更具侵袭性。此外，在单变量分析中，年龄、组织学分级和淋巴浸润状态与肿瘤特异性存活率显着相关。在多变量分析中，组织学亚型、年龄和淋巴浸润状态仍然是 CMC 的独立预后因素。腺鳞癌和间变性癌亚型与最差的预后相关。患有粉刺癌和实体癌的狗的病程比在患有良性混合肿瘤的癌的狗中观察到的更具侵袭性。此外，在单变量分析中，年龄、组织学分级和淋巴浸润状态与肿瘤特异性存活率显着相关。在多变量分析中，组织学亚型、年龄和淋巴浸润状态仍然是 CMC 的独立预后因素。腺鳞癌和间变性癌亚型与最差的预后相关。患有粉刺癌和实体癌的狗的病程比在患有良性混合肿瘤的癌的狗中观察到的更具侵袭性。此外，在单变量分析中，年龄、组织学分级和淋巴浸润状态与肿瘤特异性存活率显着相关。在多变量分析中，组织学亚型、年龄和淋巴浸润状态仍然是 CMC 的独立预后因素。在单变量分析中，组织学分级和淋巴浸润状态与肿瘤特异性存活率显着相关。在多变量分析中，组织学亚型、年龄和淋巴浸润状态仍然是 CMC 的独立预后因素。在单变量分析中，组织学分级和淋巴浸润状态与肿瘤特异性存活率显着相关。在多变量分析中，组织学亚型、年龄和淋巴浸润状态仍然是 CMC 的独立预后因素。