SHED aggregate exosomes shuttled miR-26a promote angiogenesis in pulp regeneration via TGF-β/SMAD2/3 signalling,Cell Proliferation

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SHED aggregate exosomes shuttled miR-26a promote angiogenesis in pulp regeneration via TGF-β/SMAD2/3 signalling
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-06-07 , DOI: 10.1111/cpr.13074
Meiling Wu _{1,

2} , Xuemei Liu _{1,

2,

3} , Zihan Li _{1,

2} , Xiaoyao Huang _{1,

2} , Hao Guo _{1,

2} , Xiaohe Guo ₁ , Xiaoxue Yang ₁ , Bei Li ₂ , Kun Xuan ₁ , Yan Jin ₂

Affiliation

Pulp regeneration brings big challenges for clinicians, and vascularization is considered as its determining factor. We previously accomplished pulp regeneration with autologous stem cells from deciduous teeth (SHED) aggregates implantation in teenager patients, however, the underlying mechanism needs to be clarified for regenerating pulp in adults. Serving as an important effector of mesenchymal stem cells (MSCs), exosomes have been reported to promote angiogenesis and tissue regeneration effectively. Here, we aimed to investigate the role of SHED aggregate-derived exosomes (SA-Exo) in the angiogenesis of pulp regeneration.

中文翻译：

SHED聚集外泌体穿梭于miR-26a通过TGF-β/SMAD2/3信号传导促进牙髓再生中的血管生成

牙髓再生给临床医生带来了巨大挑战，血管化被认为是其决定因素。我们之前使用来自乳牙的自体干细胞 (SHED) 聚集体植入青少年患者完成了牙髓再生，但是，需要阐明成人牙髓再生的潜在机制。作为间充质干细胞 (MSC) 的重要效应物，外泌体已被报道可有效促进血管生成和组织再生。在这里，我们旨在研究 SHED 聚集体衍生的外泌体（SA-Exo）在牙髓再生的血管生成中的作用。

更新日期：2021-07-02

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