Background: Alzheimer’s disease (AD) is the most common cause of dementia worldwide, accounting for 50–75% of all cases. While older maternal and paternal age at childbirth are established risk factors for Down syndrome which is associated with later AD, it is still not entirely clear whether parental age is a risk factor for AD. Previous studies have suggested contradictory findings. Objectives: We conducted a systematic review and meta-analysis to examine whether parental (maternal and paternal) age at birth was associated with AD and whether individuals born to younger or older parents were at an increased risk for AD. Methods: Two reviewers searched the electronic database of PubMed for relevant studies. Eligibility for the meta-analysis was based on the following criteria: (1) studies involving patients with AD and an adequate control group, (2) case control or cohort studies, (3) studies investigating parental age. All statistical analyses were completed in STATA/IC version 16. Results: Eleven studies involving 4,371 participants were included in the systematic review and meta-analysis. Meta-analysis demonstrated no significant association between maternal (weighted mean difference [WMD] 0.49, 95% CI –0.52 to 1.49, p = 0.34) and paternal age and AD (WMD 1.00, 95% CI –0.55 to 2.56, p = 0.21). Similarly, individuals born to younger (#x3c;25 years) or older parents (#x3e;35 years) did not demonstrate a differential risk for AD. Conclusions: Overall, this meta-analysis did not demonstrate an association between parental age and the risk of AD in offspring. These findings should be interpreted with caution given the limited power of the overall meta-analysis and the methodological limitations of the underlying studies as in many cases no adjustment for potential confounders was included.
Dement Geriatr Cogn Disord Extra 2021;11:140–150

中文翻译：

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父母年龄与后代患阿尔茨海默病的风险：系统评价和荟萃分析


背景：阿尔茨海默病 (AD) 是全世界痴呆症最常见的原因，占所有病例的 50-75%。虽然母亲和父亲分娩时年龄较大是唐氏综合症的既定危险因素，而唐氏综合症与后来的 AD 相关，但父母年龄是否是 AD 的危险因素尚不完全清楚。先前的研究提出了相互矛盾的发现。目的：我们进行了系统回顾和荟萃分析，以检查父母（母亲和父亲）的出生年龄是否与 AD 相关，以及年轻或年长父母所生的个体患 AD 的风险是否增加。方法：两位评审员检索 PubMed 电子数据库中的相关研究。荟萃分析的资格基于以下标准：(1) 涉及 AD 患者和足够对照组的研究，(2) 病例对照或队列研究，(3) 调查父母年龄的研究。所有统计分析均在 STATA/IC 第 16 版中完成。结果：系统评价和荟萃分析中纳入了涉及 4,371 名参与者的 11 项研究。荟萃分析表明，母亲（加权平均差 [WMD] 0.49，95% CI –0.52 至 1.49， p = 0.34）和父亲年龄与 AD 之间没有显着相关性（WMD 1.00，95% CI –0.55 至 2.56， p = 0.21） ）。同样，年轻父母（#x3c；25 岁）或年长父母（#x3e；35 岁）所生的个体也没有表现出 AD 的不同风险。结论：总体而言，这项荟萃分析并未证明父母年龄与后代 AD 风险之间存在关联。 鉴于整体荟萃分析的力量有限以及基础研究的方法学局限性，这些结果应谨慎解释，因为在许多情况下没有对潜在混杂因素进行调整。

痴呆老年认知障碍额外 2021 年；11:140–150