Transition studies have started to focus on market formation in innovation systems. This article investigates market formation in a global health transition that was instigated by drug-resistant malaria. We explore how markets for Artemisinin-based Combination Therapies (ACT) in the Greater Mekong Subregion (GMS) were formed at multiple geographical scales and locations. The study reveals the role of public institutes, academia and partnerships in early innovation system development. It demonstrates how transnational organizations created a supportive global landscape for ACT development and deployment. It then reveals how these advancements led to the formation of public-sector and private-sector ACT markets in the GMS. We illustrate how market formation activities took place on global, national and local scales and how structural couplings enabled the functioning of this global innovation system. The lessons learned are particularly relevant now that drug-resistant malaria has once more emerged in the GMS, urgently calling for new therapies and associated end-user markets.

转型研究已开始关注创新系统中的市场形成。本文调查了由耐药性疟疾引发的全球健康转型中的市场形成。我们探讨了大湄公河次区域 (GMS) 的青蒿素联合疗法 (ACT) 市场是如何在多个地理尺度和地点形成的。该研究揭示了公共机构、学术界和合作伙伴在早期创新系统发展中的作用。它展示了跨国组织如何为 ACT 的开发和部署创造了一个支持性的全球环境。然后，它揭示了这些进步如何导致 GMS 中公共部门和私营部门 ACT 市场的形成。我们说明了市场形成活动是如何在全球范围内发生的，国家和地方尺度以及结构耦合如何使这一全球创新系统发挥作用。由于耐药性疟疾再次出现在大湄公河次区域，因此吸取的经验教训尤为重要，迫切需要新的疗法和相关的最终用户市场。