PrEP delivery and routine care provide a unique opportunity to promote sexually transmitted infection (STI) prevention by both increasing STI testing frequency and creating a space for affirmative and effective safer sex counseling. This study was a feasibility and acceptability pilot of an adapted framed message intervention to increase condom use frequency with PrEP. In the formative phase, two focus groups with PrEP users (N = 7) provided feedback on a provisional loss-framed message intervention and identified potential study barriers. In the pilot trial, the adapted loss-framed message intervention was compared to a gain-framed message intervention and enhanced skills condition in a sample of PrEP users (N = 29). In terms of intervention feasibility, 58% of approached PrEP users completed the eligibility screen; 79% of those eligible enrolled in the study and 66% of enrolled participants completed the three-month follow-up. In terms of intervention acceptability, participants found the informational messages, regardless of assignment, to be moderately interesting (M = 6.24, SD = 2.97) and useful (M = 7.07, SD = 3.00), and very easy to understand (M = 9.50, SD = 0.97) on Likert-type scales ranging from 1 to 10. In terms of intervention effects, there was a small effect of the gain-framed intervention (b = .58, SE = .93, CI = -1.33, 2.48, Cohen’s d = .26) on HIV/STI risk transmission. There was a small-medium effect of both the loss- (b = 2.00, SE = .90, CI = .15, 3.85, Cohen’s d = 1.46) and gain-framed (b = 2.24, SE = .93, CI = .34, 4.15, Cohen’s d = 1.65) interventions on condom use motivation. Finally, there was a medium-large effect of both the loss- (b = .97, SE = 1.33, CI = -1.88, 3.82, Cohen’s d = .54) and gain-framed intervention (b = 1.97, SE = 1.33, CI = -.88, 4.82, Cohen’s d = .87) on condom use frequency. Further refinement and testing, in a larger -scale trial with higher ecological validity than this initial pilot intervention, is warranted.

PrEP 提供和常规护理提供了一个独特的机会，通过增加 STI 检测频率并为积极有效的安全性咨询创造空间来促进性传播感染 (STI) 的预防。这项研究是一个适应性框架信息干预的可行性和可接受性试点，以增加 PrEP 的安全套使用频率。在形成阶段，两个具有 PrEP 用户（N  = 7）的焦点小组提供了关于临时损失框架信息干预的反馈，并确定了潜在的研究障碍。在试点试验中，在 PrEP 用户样本（N = 29）。在干预可行性方面，58% 的接触过 PrEP 用户完成了资格筛选；79% 的符合条件的参与者和 66% 的参与者完成了为期三个月的随访。在干预可接受性方面，参与者发现无论分配如何，信息信息都比较有趣（M  = 6.24，SD = 2.97）和有用（M  = 7.07，SD = 3.00），并且非常容易理解（M  = 9.50 , SD = 0.97) 在从 1 到 10 的李克特类型量表上。 在干预效果方面，增益框架干预的影响很小 ( b  = .58, SE = .93, CI = -1.33, 2.48 , 科恩的d = .26) 关于 HIV/STI 风险传播。损失 ( b  = 2.00, SE = .90, CI = .15, 3.85, Cohen's d  = 1.46) 和增益框架 ( b  = 2.24, SE = .93, CI = .34, 4.15, Cohen's d  = 1.65) 对安全套使用动机的干预。最后，损失 ( b  = .97, SE = 1.33, CI = -1.88, 3.82, Cohen's d  = .54) 和增益框架干预 ( b  = 1.97, SE = 1.33 )都有中大影响, CI = -.88, 4.82, Cohen's d  = .87) 避孕套使用频率。在比初始试点干预具有更高生态有效性的更大规模试验中，进一步改进和测试是有必要的。